Concentration of trichloroethylene in breast milk and household water from Nogales, Arizona.
Concentration of trichloroethylene in breast milk and household water from Nogales, Arizona.
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DOI：
10.1021/es301380d
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发表时间：
2012-08-21
影响因子：
11.4
通讯作者：
Saez, A. Eduardo
中科院分区：
文献类型：
--
作者：
Beamer, Paloma I.;Luik, Catherine E.;Abrell, Leif;Campos, Swilma;Martinez, Maria Elena;Saez, A. Eduardo
美国环境保护署已确定母乳中三氯乙烯（TCE）（一种工业溶剂）的定量为风险评估的高度优先需求。水和牛奶样本由亚利桑那州诺加莱斯的哺乳顾问从20个家庭收集。收集了所有家庭使用的单独水样（包括自来水、瓶装水和自动售货机）：饮用、洗澡、烹饪和洗衣。进行了风险因素问卷调查。用乙醚进行液-液萃取，然后用GC-MS对水中的TCE进行定量。母乳在提取前经过均质化、脂质水解和离心。检测限为1.5 ng/mL。在20名母亲的母乳样本中，有7名检测到三氯乙烯。最大浓度为6 ng/mL。母乳中的TCE浓度与洗澡水中的浓度显着相关（ρ=0.59，p=0.008）。如果婴儿的体重指数<14，则母乳中更有可能检测到TCE（RR=5.2，p=0.02）。根据平均母乳摄入量，5%的婴儿的三氯乙烯摄入量可能超过美国环保署建议的参考剂量。这项探索性研究的结果需要进行更深入的研究，以了解母乳摄入的TCE暴露风险。
The United States Environmental Protection Agency has identified quantification of trichloroethylene (TCE), an industrial solvent, in breast milk as a high priority need for risk assessment. Water and milk samples were collected from 20 households by a lactation consultant in Nogales, Arizona. Separate water samples (including tap, bottled and vending machine) were collected for all household uses: drinking, bathing, cooking, and laundry. A risk factor questionnaire was administered. Liquid-liquid extraction with diethyl ether was followed by GC-MS for TCE quantification in water. Breast milk underwent homogenization, lipid hydrolysis and centrifugation prior to extraction. The limit of detection was 1.5 ng/mL. TCE was detected in 7 of 20 mothers’ breast milk samples. The maximum concentration was 6 ng/mL. TCE concentration in breast milk was significantly correlated with the concentration in water used for bathing (ρ=0.59, p=0.008). Detection of TCE in breast milk was more likely if the infant had a body mass index <14 (RR=5.2, p=0.02). Based on average breast milk consumption, TCE intake for 5% of the infants may exceed the proposed US EPA Reference Dose. Results of this exploratory study warrant more in depth studies to understand risk of TCE exposures from breast milk intake.
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影响因子：
10.4
作者：
Pastino GM;Yap WY;Carroquino M
通讯作者：
Carroquino M
影响因子：
3.5
作者：
Albanese, RA;Banks, HT;Potter, LK
通讯作者：
Potter, LK
影响因子：
5
作者：
Balluz, L;Philen, R;Kieszak, S
通讯作者：
Kieszak, S
DOI：
10.1080/0306731031000104713
发表时间：
2003-05-01
影响因子：
2.6
作者：
Brown, SD;Dixon, AM;Bartlett, MG
通讯作者：
Bartlett, MG
影响因子：
10.4
作者：
ANDELMAN, JB
通讯作者：
ANDELMAN, JB