Osteopontin at the Crossroads of Inflammation and Tumor Progression.
Osteopontin at the Crossroads of Inflammation and Tumor Progression.
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DOI：
10.1155/2017/4049098
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发表时间：
2017
影响因子：
4.6
通讯作者：
Chiocchetti A
中科院分区：
文献类型：
--
作者：
Castello LM;Raineri D;Salmi L;Clemente N;Vaschetto R;Quaglia M;Garzaro M;Gentilli S;Navalesi P;Cantaluppi V;Dianzani U;Aspesi A;Chiocchetti A
肿瘤和宿主细胞之间复杂的相互作用调节着肿瘤的全身播散，这一过程早期开始于原发肿瘤部位，一直持续到肿瘤细胞脱离肿瘤块并开始迁移到血液或淋巴管中。转移细胞定植在靶器官上，能够在远处存活和生长。在这种情况下，骨桥蛋白（OPN）似乎是癌细胞与宿主微环境之间串扰的关键决定因素，而宿主微环境又调节免疫逃避。OPN在几种人类癌症中过度表达，并与炎症、肿瘤进展和转移有关。因此，它代表了最具吸引力的癌症治疗靶点之一。OPN在肿瘤内由肿瘤自身或间质细胞以多种形式分泌，根据细胞类型和肿瘤微环境的不同，OPN可发挥促瘤或抗瘤作用。因此，以治疗为目的靶向OPN需要考虑到多种OPN形式在癌症形成和进展方面的异质功能。在这篇综述中，我们将描述全体性、肿瘤源性和间质性OPN的作用，强调其在炎症和肿瘤进展的十字路口的关键作用。
Complex interactions between tumor and host cells regulate systemic tumor dissemination, a process that begins early at the primary tumor site and goes on until tumor cells detach themselves from the tumor mass and start migrating into the blood or lymphatic vessels. Metastatic cells colonize the target organs and are capable of surviving and growing at distant sites. In this context, osteopontin (OPN) appears to be a key determinant of the crosstalk between cancer cells and the host microenvironment, which in turn modulates immune evasion. OPN is overexpressed in several human carcinomas and has been implicated in inflammation, tumor progression, and metastasis. Thus, it represents one of the most attracting targets for cancer therapy. Within the tumor mass, OPN is secreted in various forms either by the tumor itself or by stroma cells, and it can exert either pro- or antitumorigenic effects according to the cell type and tumor microenvironment. Thus, targeting OPN for therapeutic purposes needs to take into account the heterogeneous functions of the multiple OPN forms with regard to cancer formation and progression. In this review, we will describe the role of systemic, tumor-derived, and stroma-derived OPN, highlighting its pivotal role at the crossroads of inflammation and tumor progression.
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DOI：
10.1186/bcr3600
发表时间：
2014-01-22
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Bramwell VH;Tuck AB;Chapman JA;Anborgh PH;Postenka CO;Al-Katib W;Shepherd LE;Han L;Wilson CF;Pritchard KI;Pollak MN;Chambers AF
通讯作者：
Chambers AF
影响因子：
4.8
作者：
Buchsbaum, RJ;Connolly, BA;Feig, LA
通讯作者：
Feig, LA
影响因子：
5.3
作者：
Chambers, AF;Wilson, SM;Casson, AG
通讯作者：
Casson, AG
影响因子：
15.9
作者：
Bruemmer, D;Collins, AR;Hsueh, WA
通讯作者：
Hsueh, WA
影响因子：
5.3
作者：
Buchsbaum, RJ;Connolly, BA;Feig, LA
通讯作者：
Feig, LA