To Stick or Not to Stick: Adhesions in Orofacial Clefts.
To Stick or Not to Stick: Adhesions in Orofacial Clefts.
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DOI：
10.3390/biology11020153
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发表时间：
2022-01-18
期刊：
影响因子：
4.2
通讯作者：
Dunnwald M
中科院分区：
文献类型：
--
作者：
Antiguas A;Paul BJ;Dunnwald M
在胚胎发育过程中，细胞增殖并移动形成每个器官所必需的结构。当这些动态过程发生时，细胞必须与邻近细胞形成粘附。这些黏附体充当通讯中心，将单个细胞的行为放大为集体细胞事件。在这里，我们回顾细胞间的粘连，并重点讨论它们在面部和腭发育中的作用。形态发生需要机械力和生化信号之间的紧密协调，以通知单个细胞的行为。为了使这些发育过程正确发生，生物体需要来自三个关键胚胎层（即外胚层、中胚层和内胚层）的细胞的粘附、迁移、生长、分化和凋亡在空间和时间上进行精确的协调。细胞骨架及其重塑对于组织和放大适当形态发生所需的许多信号通路至关重要。特别是，细胞连接与细胞骨架的相互作用将单个细胞的行为放大为对发育至关重要的集体事件。在这篇综述中，我们总结了在面部和腭形成过程中发生的关键形态发生事件，以及细胞间粘连所需的蛋白质复合物。然后，我们将当前的知识整合到细胞间粘附基因突变如何导致颅面发育异常的全面回顾中，特别关注唇裂伴或不伴腭裂。
During embryonic development, cells proliferate and move to form structures essential to each organ. As these dynamic processes occur cells must form adhesions with their neighbors. These adhesions serve as communication centers to amplify the behavior of individual cells into collective cellular events. Here, we review cell-to-cell adhesions and focus on their role in the development of the face and palate. Morphogenesis requires a tight coordination between mechanical forces and biochemical signals to inform individual cellular behavior. For these developmental processes to happen correctly the organism requires precise spatial and temporal coordination of the adhesion, migration, growth, differentiation, and apoptosis of cells originating from the three key embryonic layers, namely the ectoderm, mesoderm, and endoderm. The cytoskeleton and its remodeling are essential to organize and amplify many of the signaling pathways required for proper morphogenesis. In particular, the interaction of the cell junctions with the cytoskeleton functions to amplify the behavior of individual cells into collective events that are critical for development. In this review we summarize the key morphogenic events that occur during the formation of the face and the palate, as well as the protein complexes required for cell-to-cell adhesions. We then integrate the current knowledge into a comprehensive review of how mutations in cell-to-cell adhesion genes lead to abnormal craniofacial development, with a particular focus on cleft lip with or without cleft palate.
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DOI：
10.1083/jcb.135.2.487
发表时间：
1996-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Brieher WM;Yap AS;Gumbiner BM
通讯作者：
Gumbiner BM
影响因子：
3.5
作者：
Barron, Martin J.;Brookes, Steven J.;Dixon, Michael J.
通讯作者：
Dixon, Michael J.
跨膜蛋白酪氨酸磷酸酶与钙粘蛋白-连环蛋白复合物之间的关联。
影响因子：
7.8
作者：
Kypta, R M;Su, H;Reichardt, L F
通讯作者：
Reichardt, L F
影响因子：
5.4
作者：
Cocchi, F;Menotti, L;Campadelli-Fiume, G
通讯作者：
Campadelli-Fiume, G
影响因子：
5.6
作者：
Choi, HJ;Weis, WI
通讯作者：
Weis, WI