Descriptive epidemiology of selected olfactory tumors.
Descriptive epidemiology of selected olfactory tumors.
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DOI：
10.1007/s11060-010-0140-x
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发表时间：
2010-10
影响因子：
3.9
通讯作者：
McCarthy BJ
中科院分区：
文献类型：
--
作者：
Villano JL;Bressler L;Propp JM;Valyi-Nagy T;Martin IK;Dolecek TA;McCarthy BJ
嗅觉肿瘤，特别是嗅神经母细胞瘤（ON）和神经内分泌分化癌（CND）极为罕见，并且可用的描述性流行病学信息很少。本研究的目的是使用基于人口的大型癌症发病率数据库更全面地描述选定的嗅觉肿瘤。对 1973 年至 2006 年选定的鼻腔 (C30.0) 和副窦 (C31.0–31.9) 肿瘤的监测、流行病学和最终结果 (SEER) 9 登记有限使用数据进行了审查。使用 SEER*Stat v6.5.2 估计频率、发病率和相对生存率。大多数病例为鳞状细胞癌（SCC），而ON的发生率高于CND。 ON 的发病率在 60-79 岁年龄组中最高，而 SCC 的发病率在 80 岁以上年龄组中最高。对于 CND，最大年龄组的发病率趋于平稳。 ON 的存活率最高（诊断后 5 年存活率 > 70%），CND 存活率最低（5 年存活率 44%）。与单纯手术相比，辅助放射治疗并不能提高 ON 患者的生存率。在鳞状细胞癌中，接受辅助放疗的患者的生存率比仅接受手术的患者更差。我们的分析证实了一些先前发布的信息，并添加了有关 ON 和 CND 的发病率和人口统计数据的新信息。此外，我们的分析证明辅助放射对 ON 缺乏益处。在患有这些罕见疾病的患者中进行前瞻性试验是不可行的，并且强调了注册数据在了解嗅觉肿瘤中的重要性。
Olfactory tumors, especially olfactory neuroblastomas (ON) and carcinomas with neuroendocrine differentiation (CND), are extremely rare, and little descriptive epidemiologic information is available. The objective of this study was to more fully describe selected olfactory tumors using a large population-based cancer incidence database. The Surveillance, Epidemiology and End Results (SEER) 9 registries limited-use data were reviewed from 1973 to 2006 for selected nasal cavity (C30.0) and accessory sinus (C31.0–31.9) tumors. Frequencies, incidence rates, and relative survival rates were estimated using SEER*Stat, v6.5.2. The majority of cases were squamous cell carcinoma (SCC), while the incidence of ON was greater than CND. For ON, the incidence was highest in the 60–79 year age group, while for SCC, the incidence was highest in the 80+ year age group. For CND, the incidence leveled off in the oldest age groups. Survival rates were highest for ON (>70% alive at 5 years after diagnosis) and poorest for CND (44% alive at 5 years). Adjuvant radiation therapy did not improve survival over surgery alone in ON. In SCC, survival was worse in patients who received adjuvant radiation compared to patients who had surgery alone. Our analysis confirms some previously published information, and adds new information about the incidence and demographics of ON and CND. In addition, our analysis documents the lack of benefit of adjuvant radiation in ON. It is not feasible to conduct prospective trials in patients with these rare diseases, and the importance of registry data in learning about olfactory tumors is emphasized.
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DOI：
10.1002/hed.21022
发表时间：
2009-06-01
影响因子：
2.9
作者：
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影响因子：
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