Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial.
Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial.
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DOI：
10.7326/0003-4819-149-6-200809160-00003
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发表时间：
2008-09-16
影响因子：
39.2
通讯作者：
Fairclough, Diane L.
中科院分区：
文献类型：
--
作者：
Kutner, Jean S.;Smith, Marlaine C.;Corbin, Lisa;Hemphill, Linnea;Benton, Kathryn;Mellis, B. Karen;Beaty, Brenda;Felton, Sue;Yamashita, Traci E.;Bryant, Lucinda L.;Fairclough, Diane L.
Small studies of variable quality suggest that massage therapy may relieve pain and other symptoms. Evaluate efficacy of massage for decreasing pain and symptom distress and improving quality of life among persons with advanced cancer. Multi-site randomized clinical trial. Population-based Palliative Care Research Network (PoPCRN). 380 adults with advanced cancer experiencing moderate-severe pain; 90% were enrolled in hospice. Six 30-minute massage or simple touch sessions over two weeks. Primary outcomes were immediate (Memorial Pain Assessment Card, MPAC, 0 – 10 scale) and sustained (Brief Pain Inventory, BPI, 0 – 10 scales) change in pain. Secondary outcomes were immediate change in mood (MPAC 0 – 10 scale) and 60-second heart and respiratory rates and sustained change in quality of life (McGill Quality of Life Questionnaire, MQOL, 0 – 10 scale), symptom distress (Memorial Symptom Assessment Scale, MSAS, 0 – 4 scale), and analgesic medication use (parenteral morphine equivalents (milligrams/24 hours). Immediate outcomes were obtained just prior to and following each treatment session. Sustained outcomes were obtained at baseline and weekly for 3 weeks. 298 were included in the immediate outcome analysis and 348 in the sustained outcome analysis. 82 did not receive any allocated study treatments (37 massage, 45 control). Both groups demonstrated immediate improvement in pain (massage -1.87 points (CI, -2.07, -1.67), control -0.97 points (CI, -1.18, -0.76)) and mood (massage 1.58 points (CI, 1.40, 1.76), control 0.97 points (CI, 0.78, 1.16)). Massage was superior for both pain and mood (mean difference 0.90 and 0.61 points, respectively, P<0.001). There were no between group mean differences over time in pain (BPI Mean 0.07 (CI, -0.23, 0.37), BPI Worst -0.14 (CI, -0.59, 0.31)), quality of life (MQOL Overall 0.08 (CI, -0.37, 0.53)), symptom distress (MSAS Global Distress Index -0.002 (CI, -0.12, 0.12)), or analgesic medication use (parenteral morphine equivalents -0.10 (CI, -0.25, 0.05). The immediate outcome measures were obtained by unblinded study therapists, possibly leading to reporting bias and the overestimation of beneficial effect. The generalizability to all advanced cancer patients is uncertain. The differential beneficial effect of massage therapy over simple touch is not conclusive in the absence of a “usual care” control arm. Massage may have immediately beneficial effects on pain and mood among patients with advanced cancer. Given the lack of sustained effects and the observed improvements in both study arms, the potential benefits of attention and simple touch should also be considered in this population.
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