Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial.
Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial.
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DOI：
10.1186/1472-6882-12-26
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发表时间：
2012-03-29
影响因子：
--
通讯作者：
Hinderliter AL
中科院分区：
文献类型：
--
作者：
Asher GN;Viera AJ;Weaver MA;Dominik R;Caughey M;Hinderliter AL
几个世纪以来，山楂提取物一直用于治疗心血管疾病。最近的试验已经证明了它对治疗心力衰竭的有效性，几项小型试验的结果表明它可能会降低血压。然而，很少有已发表的证据来指导其剂量。山楂的降血压作用与一氧化氮介导的血管舒张有关。本研究的目的是调查山楂提取物剂量和肱动脉血流介导的舒张（FMD），一氧化氮释放的间接措施之间的关系。我们采用四阶段交叉设计来评估肱动脉FMD对安慰剂或山楂提取物（标准化为每250 mg提取物50 mg低聚原花青素）的反应。随机顺序剂量的山楂提取物（1000毫克，1500毫克，2500毫克）和安慰剂分配给每个参与者。每天两次给药，持续3 1/2天，然后进行FMD和4天洗脱，然后进入下一个给药期。21名高血压前期或轻度高血压成人完成了研究。没有证据表明我们的主要结局（FMD百分比）或任何次要结局（肱动脉直径和血压的绝对变化）存在剂量反应效应。大多数参与者表示，如果有证据表明山楂可以降低血压，他们可能会将其与生活方式改变或抗高血压药物结合使用或代替。我们没有发现山楂提取物对口蹄疫有剂量反应效应的证据。如果山楂具有降低血压的作用，那么它可能是通过NO非依赖性机制介导的。该试验已在ClinicalTrials.gov上注册，这是美国国立卫生研究院的一项服务：NCT 01331486。
Hawthorn extract has been used for cardiovascular diseases for centuries. Recent trials have demonstrated its efficacy for the treatment of heart failure, and the results of several small trials suggest it may lower blood pressure. However, there is little published evidence to guide its dosing. The blood pressure lowering effect of hawthorn has been linked to nitric oxide-mediated vasodilation. The aim of this study was to investigate the relationship between hawthorn extract dose and brachial artery flow mediated dilation (FMD), an indirect measure of nitric oxide release. We used a four-period cross-over design to evaluate brachial artery FMD in response to placebo or hawthorn extract (standardized to 50 mg oligomeric procyanidin per 250 mg extract). Randomly sequenced doses of hawthorn extract (1000 mg, 1500 mg, and 2500 mg) and placebo were assigned to each participant. Doses were taken twice daily for 3 1/2 days followed by FMD and a 4-day washout before proceeding to the next dosing period. Twenty-one prehypertensive or mildly hypertensive adults completed the study. There was no evidence of a dose-response effect for our main outcome (FMD percent) or any of our secondary outcomes (absolute change in brachial artery diameter and blood pressure). Most participants indicated that if given evidence that hawthorn could lower their blood pressure, they would be likely to use it either in conjunction with or instead of lifestyle modification or anti-hypertensive medications. We found no evidence of a dose-response effect of hawthorn extract on FMD. If hawthorn has a blood pressure lowering effect, it is likely to be mediated via an NO-independent mechanism. This trial has been registered with ClinicalTrials.gov, a service of the U.S. National Institutes of Health: NCT01331486.
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影响因子：
3.4
作者：
Brixius, Klara;Willms, Sonja;Schwinger, Robert H. G.
通讯作者：
Schwinger, Robert H. G.
影响因子：
2.9
作者：
Chang, Q;Zuo, Z;Chow, MSS
通讯作者：
Chow, MSS
影响因子：
5.3
作者：
Rajendran, S;Deepalakshmi, PD;Devaraj, SN
通讯作者：
Devaraj, SN
影响因子：
37.8
作者：
EGASHIRA, K;INOU, T;TAKESHITA, A
通讯作者：
TAKESHITA, A
影响因子：
5.3
作者：
Shimbo, Daichi;Grahame-Clarke, Cairistine;Homma, Shunichi
通讯作者：
Homma, Shunichi