Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration.
Association of Low Luminance Questionnaire With Objective Functional Measures in Early and Intermediate Age-Related Macular Degeneration.
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DOI：
10.1167/iovs.17-22528
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发表时间：
2018-01-01
影响因子：
4.4
通讯作者：
Lad EM
中科院分区：
文献类型：
--
作者：
Thompson AC;Luhmann UFO;Stinnett SS;Vajzovic L;Horne A;Toth CA;Cousins SW;Lad EM
确定低亮度问卷（LLQ）评分是否与早期和中期年龄相关性黄斑变性（AMD）的视觉功能客观测量相关。对患有早期AMD黄斑相关眼病研究（AREDS）第2阶段，N = 33）、中期AMD（AREDS第3阶段，N = 47）和年龄匹配的健康对照（N = 21）的受试者的横断面研究。受试者接受了LLQ访谈。进行的心理物理学测试包括最佳矫正视力（BCVA）、中间视觉微视野、暗适应测定（DA）、低亮度视力（LLVA）和锥形对比度测试（CCT）。低亮度缺陷（LLD）是在明视与低亮度设置下阅读字母数量的差异。采用线性回归评估LLQ与视功能测试评分之间的关系。中度AMD受试者的LLQ综合评分显著较低（平均值= 75.8 ± 16.7;中位数= 76，范围[29，97]）与早期AMD相比（平均值= 85.3 ± 13.3;中位数= 88，范围[50，100]，P = 0.007）或对照组（平均值= 91.4 ± 6.5;中位数= 94，范围[79，99]，P < 0.001）。LLQ综合评分与计算机BCVA相关（β = 0.516），两个背景亮度下的计算机LLVA（1.3 cd/m2，β = 0.660; 0.5 cd/m2，β = 0.489）沿着其各自的计算机化LD（β = −0.531和−0.467）、杆截距（β = −0.312）和CCT绿色（β = 0.183）（均P < 0.05）。在校正AMD后，只有计算机化LLVA和计算机化LLD与对照状态相比仍具有统计学意义（P < 0.05）。在AMD受试者中，LLQ综合评分分别与1.3和0.5 cd/m2亮度水平下的计算机化LLVA（β = 0.622和0.441）和LLD（β =-0.795和-0.477）显著相关，并且在调整AMD严重程度后，这些相关性仍然显著（P < 0.05）。在早期和中期AMD受试者中，LLQ评分与计算机LLVA和LLD显著相关。LLQ是一个有用的以患者为中心的功能性测量视力损害的早期和中期AMD。
To determine whether Low Luminance Questionnaire (LLQ) scores are associated with objective measures of visual function in early and intermediate age-related macular degeneration (AMD). Cross-sectional study of subjects with early AMD Age-Related Eye Disease Study (AREDS) stage 2, N = 33), intermediate AMD (AREDS stage 3, N = 47), and age-matched healthy controls (N = 21). Subjects were interviewed with the LLQ. Psychophysical tests performed included best-corrected visual acuity (BCVA), mesopic microperimetry, dark adaptometry (DA), low luminance visual acuity (LLVA), and cone contrast test (CCT). Low luminance deficit (LLD) was the difference in the number of letters read under photopic versus low luminance settings. The relationship between LLQ and visual function test scores was assessed with linear regression. Subjects with intermediate AMD had significantly lower LLQ composite scores (mean = 75.8 ± 16.7; median = 76, range [29, 97]) compared with early AMD (mean = 85.3 ± 13.3; median = 88, range [50, 100], P = 0.007) or controls (mean = 91.4 ± 6.5; median = 94, range [79, 99], P < 0.001) in the overall cohort. LLQ composite scores were associated with computerized BCVA (β = 0.516), computerized LLVA at two background luminance (1.3 cd/m2, β = 0.660; 0.5 cd/m2, β = 0.489) along with their respective computerized LLDs (β = −0.531 and −0.467), rod intercept (β = −0.312), and CCT green (β = 0.183) (all P < 0.05). Only the computerized LLVAs and computerized LLDs remained statistically significant after adjusting for AMD versus control status (P < 0.05). Among AMD subjects, LLQ composite scores were significantly associated with the computerized LLVAs (β = 0.622 and 0.441) and LLDs (β = −0.795 and −0.477) at both the 1.3 and 0.5 cd/m2 luminance levels, respectively, and these associations remained significant after adjusting for AMD severity (P < 0.05). Among subjects with early and intermediate AMD, LLQ scores were significantly associated with computerized LLVA and LLD. LLQ is a useful patient-centered functional measure of visual impairment in early and intermediate AMD.
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影响因子：
4.4
作者：
Jackson, Gregory R.;Scott, Ingrid U.;Edwards, John G.
通讯作者：
Edwards, John G.
影响因子：
4.1
作者：
STEINMETZ, RL;HAIMOVICI, R;BIRD, AC
通讯作者：
BIRD, AC
影响因子：
--
作者：
Kassoff, A;Kassoff, J;Chew, EY
通讯作者：
Chew, EY
影响因子：
4.4
作者：
Owsley, C;McGwin, G;Kallies, K
通讯作者：
Kallies, K
影响因子：
13.7
作者：
Scilley, K;Jackson, GR;Owsley, C
通讯作者：
Owsley, C