Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse.
Muscle wasting and interleukin-6-induced atrogin-I expression in the cachectic Apc ( Min/+ ) mouse.
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DOI：
10.1007/s00424-008-0574-6
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发表时间：
2009-03
影响因子：
4.5
通讯作者：
Carson, James A.
中科院分区：
文献类型：
--
作者：
Baltgalvis, Kristen A.;Berger, Franklin G.;Pena, Maria Marjorette O.;Davis, J. Mark;White, James P.;Carson, James A.
Interleukin-6 (IL-6) is necessary for cachexia in ApcMin/+ mice, but the mechanisms inducing this myofiber wasting have not been established. The purpose of this study was to examine gastrocnemius muscle wasting in the ApcMin/+ mouse and to determine IL-6 regulated mechanisms contributing to muscle loss. Gastrocnemius type IIB mean fiber cross-sectional area (CSA) from ApcMin/+ mice decreased 32% between 13- and 22-wks of age. ApcMin/+ mice lacking IL-6 did not have type IIB fiber atrophy, while over-expression of circulating IL-6 exacerbated the loss of type IIB fiber CSA in ApcMin/+ mice. Muscle Atrogin-I mRNA expression was induced at least 9-fold at 18- and 22-wks of age compared to 13-wk-old mice. Atrogin-I gene expression was also induced by over-expression of circulating IL-6. These data suggest that high circulating IL-6 levels induce type IIB fiber CSA loss in ApcMin/+ mice, and circulating IL-6 is sufficient to regulate Atrogin-I gene expression in cachectic mice.
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影响因子：
15.9
作者：
Acharyya, S;Ladner, KJ;Guttridge, DC
通讯作者：
Guttridge, DC
DOI：
10.1097/01.mco.0000078983.18774.cc
发表时间：
2003-07-01
影响因子：
3.1
作者：
Argilés, JM;Busquets, S;López-Soriano, FJ
通讯作者：
López-Soriano, FJ
DOI：
10.1152/ajpcell.2001.280.3.c637
发表时间：
2001-03-01
影响因子：
5.5
作者：
Allen, DL;Harrison, BC;Leinwand, LA
通讯作者：
Leinwand, LA
影响因子：
3.5
作者：
Fattori, E;Cappelletti, M;La Monica, N
通讯作者：
La Monica, N
影响因子：
11.2
作者：
Kwak, KS;Zhou, XL;Han, HQ
通讯作者：
Han, HQ