Lateralized contributions of the cerebral cortex, parabrachial nucleus, and amygdala to acquisition and retrieval of passive avoidance reaction in rats: a functional ablation study.
Lateralized contributions of the cerebral cortex, parabrachial nucleus, and amygdala to acquisition and retrieval of passive avoidance reaction in rats: a functional ablation study.
复制标题
大脑皮层、臂旁核和杏仁核的偏侧化对大鼠被动回避反应的获得和恢复的贡献：一项功能性消融研究。
作者：
G. Tassoni;C. Bucherelli;J. Bureš
用扩散性抑制可逆性阻断大鼠新皮层和河豚毒素（TTX）可逆性阻断大鼠臂旁核（PBN）和杏仁核（AMG），研究被动回避反应（PAR）脑电描记的偏侧化。在实验1中，PAR收购不中断审判后TTX应用到PBN或AMG或这两个结构在同一半球，但受损时，AMG和PBN被封锁在相反的半球。在实验2中，检索与完整的大脑收购PAR不受损害的单方面TTX封锁的AMG。在实验3中，在一侧半球中通过试验后TTX阻断AMG和PBN获得PAR。对侧或同侧半球的功能性皮质剥脱分别诱导PAR恢复的全部或部分阻滞，而AMG的阻滞则无效。可以得出结论，PAR收购需要同侧的AMG和PBN的相互作用，这两个半皮质有助于差异检索在这种条件下形成的记忆痕迹。
Reversible blockade of the neocortex by spreading depression and of the parabrachial nucleus (PBN) and amygdala (AMG) by tetrodotoxin (TTX) injection was used to study lateralization of passive avoidance reaction (PAR) engrams in rats. In Experiment 1, PAR acquisition was not disrupted by posttrial TTX applied into the PBN or AMG or into both of these structures in the same hemisphere but was impaired when the AMG and PBN were blocked in opposite hemispheres. In Experiment 2, retrieval of PAR acquired with intact brain was not impaired by unilateral TTX blockade of the AMG. In Experiment 3, PAR was acquired with posttrial TTX blockade of the AMG and PBN in one hemisphere. Full or partial block of PAR retrieval was induced by functional decortication of the contra- or ipsilateral hemisphere, respectively, whereas blockade of either AMG was ineffective. It is concluded that PAR acquisition requires ipsilateral interaction of the AMG and PBN and that the two hemicortices contribute differentially to the retrieval of engrams formed under such conditions.
杏仁核复合体损伤通过食欲和厌恶强化对任务的保留产生不同的影响。
影响因子：
1.9
作者：
Cahill,L;McGaugh,JL
通讯作者：
McGaugh,JL