A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity.
A pleomorphic carcinoma of the lung producing multiple cytokines and forming a rapidly progressive mass-like opacity.
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DOI：
10.1186/1471-2407-14-588
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发表时间：
2014-08-13
期刊：
影响因子：
3.8
通讯作者：
Fukui M
中科院分区：
文献类型：
--
作者：
Matsumoto M;Nakayama T;Inoue D;Takamatsu K;Itotani R;Ishitoko M;Suzuki S;Sakuramoto M;Yuba Y;Yoshie O;Takemura M;Fukui M
据报道，肺癌细胞会产生细胞因子，导致全身反应。很少有报道表明这些细胞因子诱导肺癌周围炎性物质的形成。我们遇到一位患有多形性肺癌的患者。该肿瘤产生白细胞介素 (IL)-8、粒细胞集落刺激因子和 IL-6，进而在肿瘤周围招募炎症细胞，例如 CD8 阳性淋巴细胞，导致肿瘤阴影快速生长。除了计算机断层扫描等传统放射学方法之外，18 F-氟脱氧葡萄糖正电子发射断层扫描还可以检测肿瘤周围的免疫反应。
Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung cancers. We encountered a patient with a pleomorphic carcinoma of the lung. This tumor produced interleukin (IL)-8, granulocyte colony-stimulating factor and IL-6, which in turn recruited inflammatory cells, such as CD8 positive lymphocytes, around the tumor, resulting in a rapidly growing tumor shadow. 18 F-fluoro-deoxy-glucose positron emission tomography, in addition to a conventional radiological approach such as computed tomography, may detect immunological responses around a tumor.
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