RIP1-mediated regulation of lymphocyte survival and death responses.
RIP1-mediated regulation of lymphocyte survival and death responses.
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DOI：
10.1007/s12026-011-8249-3
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发表时间：
2011-12
影响因子：
4.4
通讯作者：
Farabaugh, Mathew
中科院分区：
文献类型：
--
作者：
Zhang, Jianke;Zhang, Haibing;Li, Jinghe;Rosenberg, Stephen;Zhang, Emily C.;Zhou, Xiaohui;Qin, Fengsong;Farabaugh, Mathew
RIP1 is an adaptor serine/threonine kinase associated with the signaling complex of death receptors (DRs) including Fas, TNFR1, and TRAIL-Rs which can initiate apoptosis. While DRs are dispensable throughout development, RIP1 deletion results in perinatal lethality. The developmental defect caused by absence of RIP1 remains unexplained. In previous studies, RIP1-deficient hematopoietic progenitors failed to reconstitute the T cell compartment and our recent data indicate a new role for RIP1 in TCR-induced activation of the prosurvival NF-κB pathway. Here we show that RIP1 is also critical for B cell development. In addition, RIP1−/− B cells stimulated through LPS/TLR4 are impaired in NF-κB activation but have no major defect in the Akt pathway. Recently, RIP1 has also emerged as a critical player in necrosis-like death, necroptosis, in various cell lines. We have demonstrated that RIP1 deficiency can reverse the embryonic and T cell proliferation defects in mice lacking FADD, a caspase adaptor protein, which indicates a potential role for RIP1 in mediating in vivo necroptosis. We provide an overview and discussion of the accumulating data revealing insights into the diverse functions of RIP1 in survival and death signaling in lymphocytes.
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影响因子：
4.4
作者：
Beisner, DR;Ch'en, IL;Hedrick, SM
通讯作者：
Hedrick, SM
影响因子：
16
作者：
Ea, CK;Deng, L;Chen, ZJJ
通讯作者：
Chen, ZJJ
DOI：
10.1083/jcb.143.5.1353
发表时间：
1998-11-30
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kawahara A;Ohsawa Y;Matsumura H;Uchiyama Y;Nagata S
通讯作者：
Nagata S
影响因子：
64.5
作者：
Cho YS;Challa S;Moquin D;Genga R;Ray TD;Guildford M;Chan FK
通讯作者：
Chan FK
影响因子：
14.8
作者：
Degterev, Alexei;Hitomi, Junichi;Yuan, Junying
通讯作者：
Yuan, Junying