Image-Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System.
Image-Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System.
复制标题
磁共振成像系统成像引导磁热籽导航和肿瘤消融。
DOI：
10.1002/advs.202105333
复制
发表时间：
2022-04
期刊：
影响因子：
15.1
通讯作者：
Lythgoe, Mark F.
中科院分区：
文献类型：
--
作者：
Baker, Rebecca R.;Payne, Christopher;Yu, Yichao;Mohseni, Matin;Connell, John J.;Lin, Fangyu;Harrison, Ian F.;Southern, Paul;Rudrapatna, Umesh S.;Stuckey, Daniel J.;Kalber, Tammy L.;Siow, Bernard;Thorne, Lewis;Punwani, Shonit;Jones, Derek K.;Emberton, Mark;Pankhurst, Quentin A.;Lythgoe, Mark F.
关键词：
药物治疗以一系列毒性的形式对患者进行控制，这会产生成本并降低生活质量。磁共振导航是一项新兴技术，可使用磁共振成像（MRI）系统对体内的磁标记治疗和器械进行图像引导远程控制。微创影像引导消融（MINIMA）是一种新型微创MRI引导消融技术，有可能避免传统的毒性。它包括使用MRI扫描仪产生的磁推进梯度导航到靶部位的热种子，然后使用MR兼容的热消融器械诱导局部细胞死亡。作者证明了使用MRI系统（0.3 mm）通过脑组织进行精确的热种子成像和导航，并在体外和体内皮下肿瘤内进行热消融，通过加热持续时间精细控制局灶消融体积。MINIMA是一种新型的治疗诊断平台，结合了成像、导航和加热，在单个设备中提供诊断和治疗。微创图像引导消融是一种新型治疗，使用磁共振成像（MRI）扫描仪提供精确的局灶性消融治疗。使用MRI扫描仪产生的磁场梯度将铁磁热籽导航到靶点，然后使用MR兼容射频线圈加热，以进行局部热消融。
Medical therapies achieve their control at expense to the patient in the form of a range of toxicities, which incur costs and diminish quality of life. Magnetic resonance navigation is an emergent technique that enables image‐guided remote‐control of magnetically labeled therapies and devices in the body, using a magnetic resonance imaging (MRI) system. Minimally INvasive IMage‐guided Ablation (MINIMA), a novel, minimally invasive, MRI‐guided ablation technique, which has the potential to avoid traditional toxicities, is presented. It comprises a thermoseed navigated to a target site using magnetic propulsion gradients generated by an MRI scanner, before inducing localized cell death using an MR‐compatible thermoablative device. The authors demonstrate precise thermoseed imaging and navigation through brain tissue using an MRI system (0.3 mm), and they perform thermoablation in vitro and in vivo within subcutaneous tumors, with the focal ablation volume finely controlled by heating duration. MINIMA is a novel theranostic platform, combining imaging, navigation, and heating to deliver diagnosis and therapy in a single device. Minimally invasive image‐guided ablation is a novel therapy that uses a magnetic resonance imaging (MRI) scanner to deliver precise focal ablation therapy. A ferromagnetic thermoseed is navigated to the target using the magnetic field gradients generated by the MRI scanner and then heated using an MR‐compatible radiofrequency coil to deliver localized thermoablation.
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影响因子：
8
作者：
Kalber TL;Ordidge KL;Southern P;Loebinger MR;Kyrtatos PG;Pankhurst QA;Lythgoe MF;Janes SM
通讯作者：
Janes SM
影响因子：
120.7
作者：
Mack, MJ
通讯作者：
Mack, MJ
影响因子：
3.1
作者：
Illing, Rowland;Emberton, Mark
通讯作者：
Emberton, Mark
DOI：
10.1016/j.jmbbm.2015.02.024
发表时间：
2015-06
影响因子：
3.9
作者：
Budday, Silvia;Nay, Richard;de Rooij, Rijk;Steinmann, Paul;Wyrobek, Thomas;Ovaert, Timothy C.;Kuhl, Ellen
通讯作者：
Kuhl, Ellen
DOI：
10.1115/1.1785803
发表时间：
2004-08-01
影响因子：
1.7
作者：
Larson, BT;Erdman, AG;Koutlas, LG
通讯作者：
Koutlas, LG