Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features.
Transcriptional profile of tuberculosis antigen-specific T cells reveals novel multifunctional features.
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DOI：
10.4049/jimmunol.1401151
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发表时间：
2014-09-15
期刊：
影响因子：
--
通讯作者：
Peters B
中科院分区：
文献类型：
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作者：
Arlehamn CL;Seumois G;Gerasimova A;Huang C;Fu Z;Yue X;Sette A;Vijayanand P;Peters B
In latent tuberculosis infection (LTBI) spread of the bacteria is contained by a persistent immune response, which includes CD4+ T cells as important contributors. Here we show that TB-specific CD4+ T cells have a characteristic chemokine expression signature (CCR6+CXCR3+CCR4−), and that the overall number of these cells is significantly increased in LTBI donors compared to healthy subjects. We have comprehensively characterized the transcriptional signature of CCR6+CXCR3+CCR4− cells and find significant differences to conventional Th1, Th17 and Th2 cells, but no major changes between healthy and LTBI donors. CCR6+CXCR3+CCR4− cells display linage-specific signatures of both Th1 and Th17 cells, but also have a unique gene expression program including genes associated with susceptibility to TB, enhanced T cell activation, enhanced cell survival, and induction of a cytotoxic program akin to CTL cells. Overall, the gene expression signature of CCR6+CXCR3+CCR4− cells reveals characteristics important for controlling latent TB infections.
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DOI：
10.1093/bioinformatics/btp074
发表时间：
2009-04-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Bengtsson H;Ray A;Spellman P;Speed TP
通讯作者：
Speed TP
DOI：
10.1093/bioinformatics/btu638
发表时间：
2015-01-15
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Anders S;Pyl PT;Huber W
通讯作者：
Huber W
DOI：
10.4049/jimmunol.1103556
发表时间：
2012-05-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Arlehamn CS;Sidney J;Henderson R;Greenbaum JA;James EA;Moutaftsi M;Coler R;McKinney DM;Park D;Taplitz R;Kwok WW;Grey H;Peters B;Sette A
通讯作者：
Sette A
DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
64.8
作者：
通讯作者：
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