Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression.
Nuclear actin and actin-binding proteins in the regulation of transcription and gene expression.
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DOI：
10.1111/j.1742-4658.2009.06986.x
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发表时间：
2009-05
期刊：
影响因子：
--
通讯作者：
Wen JK
中科院分区：
文献类型：
--
作者：
Zheng B;Han M;Bernier M;Wen JK
核肌动蛋白参与了所有三种RNA聚合酶的转录、染色质重塑、hnRNP复合体的形成以及组蛋白修饰物对活性基因的招募。此外，肌动蛋白结合蛋白(ABPs)控制肌动蛋白的成核、捆绑、细丝封顶、碎裂和单体在细胞质中的可获得性。近年来，肌动蛋白和ABPs在转录调控亚细胞定位中的作用受到越来越多的关注。本文就核肌动蛋白的转录调控、肌特异性基因表达的调控、核受体和ABPs的转录复合体等方面的研究进展作一综述。其中，STAR和ABLIM调控肌动蛋白动力学和依赖SRF的肌肉特异性基因表达。在功能和结构上不相关的胞浆ABPs与核受体协同作用，调节其反式激活。此外，ABPs还参与转录复合体的形成。
Nuclear actin is involoved in transcription of all three RNA polymerases, chromatin remodeling, and formation of hnRNP complexes as well as recruitment of histone modifier to the active gene. In addition, actin-binding proteins (ABPs) control actin nucleation, bundling, filament capping, fragmentation, and monomer availability in the cytoplasm. In recent years, more and more attention is on the role of actin and ABPs in the modulation of the subcellular localization of transcriptional regulators. This review focuses on the recent developments about transcription and transcriptional regulation by nuclear actin, regulation of muscle-specific gene expression, nuclear receptor and transcription complexes by ABPs. Among them, STARS and ABLIM regulate actin dynamics and SRF-dependent muscle-specific gene expression. Functionally and structurally unrelated cytoplasmic ABPs interact cooperatively with nuclear receptor and regulate its transactivation. Furthermore, ABPs also participate in the formation of transcription complexes.
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4
作者：
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