Influences of neonatal gonadectomy or androgen exposure on the sexual differentiation of the rat ventromedial hypothalamus.
Influences of neonatal gonadectomy or androgen exposure on the sexual differentiation of the rat ventromedial hypothalamus.
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新生儿性腺切除术或雄激素暴露对大鼠腹内侧下丘脑性别分化的影响。
DOI：
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Y. Sakuma
中科院分区：
文献类型：
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作者：
Y. Sakuma
电刺激中脑中央灰质后，在 137 只乌拉坦麻醉的大鼠的腹内侧下丘脑的 830 个神经元的细胞外记录了逆向动作电位。确定了 25 名正常男性 (n = 157) 和 30 名成人切除卵巢的女性 (n = 167) 以及 36 名新生儿去势男性 (n = 223) 和 46 名接受丙酸睾酮治疗的新生儿女性 (n = 223) 的每次反应的逆向尖峰潜伏期（范围：1.4-45.0 ms）和刺激阈值（85-1800 microA）。 = 283）。每组动物中逆向尖峰潜伏期的频率分布是多峰的，并且各组之间存在差异。与正常男性相比，切除卵巢的女性中显着更多的细胞具有分别在 6.0-11.0 ms 和 14.0-20.0 ms 两个范围内的逆向峰值潜伏期。通过在产后早期对雌性施用睾酮或对雄性进行去势来改变具有较长潜伏期的细胞的比例。潜伏期较短的神经元群体能够承受内分泌操作。成人服用雌激素可显着降低卵巢切除女性和新生儿阉割男性的逆向激活阈值。经过睾酮治疗、持续发情的雌性在成年后进行卵巢切除或补充雌激素后，高阈值没有变化。结论是，投射到中央灰质的下丘脑神经元中存在性别二态性，并且这种差异至少部分取决于新生儿内分泌治疗。
Antidromic action potentials were recorded extracellularly from 830 neurones in the ventromedial hypothalamus of 137 urethane‐anaesthetized rats following electrical stimulation of the central grey matter of the mesencephalon. Antidromic spike latency (range: 1.4‐45.0 ms) and stimulus threshold (85‐1800 microA) were determined for each response in twenty‐five normal males (n = 157) and thirty females ovariectomized as adults (n = 167) as well as in thirty‐six neonatally castrated males (n = 223) and forty‐six females neonatally treated with testosterone propionate (n = 283). Frequency distribution of the antidromic spike latency was multimodal in each group of animals, and was different between the groups. Significantly more of the cells had antidromic spike latencies within two ranges of 6.0‐11.0 ms and 14.0‐20.0 ms, respectively, in the ovariectomized females than in the normal males. The proportion of cells with longer latencies was modified by testosterone administration to females or castration of males during the early post‐natal period. Neuronal populations with shorter latencies withstood endocrine manipulations. Oestrogen administration to adults significantly decreased antidromic activation thresholds in ovariectomized females and neonatally castrated males. High threshold values in the testosterone‐treated, constant oestrous females did not change after ovariectomy as adults or oestrogen supplementation. It is concluded that sexual dimorphism exists in the hypothalamic neurones shown to project to the central grey and that difference depends at least partially on neonatal endocrine treatments.
影响因子：
2.5
作者：
Sakuma,Y;Pfaff,DW
通讯作者：
Pfaff,DW
具有髓质投射的雌性大鼠中央灰细胞的兴奋性：下丘脑刺激和雌激素治疗产生的变化。
影响因子：
2.5
作者：
Sakuma,Y;Pfaff,DW
通讯作者：
Pfaff,DW