Design of novel protein building modules and modular architectures.
Design of novel protein building modules and modular architectures.
复制标题
新型蛋白质构建模块和模块化架构的设计。
DOI：
10.1016/j.sbi.2020.04.006
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发表时间：
2020
影响因子：
6.8
通讯作者：
R. Jerala
中科院分区：
文献类型：
--
作者：
Fabio Lapenta;R. Jerala
HighlightsDesignable non-natural protein folds are estimated to exceed the number of natural folds.Propagation of protein modules can be harnessed for designing novel protein architectures.Beta-sheet elements have been successfully implemented in de novo designed protein structures.α-helical elements are particularly versatile for obtaining protein architectures not present in nature.Miniproteins represent a valuable contribution to the pool of protein modules available for protein design.Nature uses only a limited number of protein topologies and while several folds have evolved independently over time, there are clearly many possible topologies that have not been explored by evolution. With recent advances of protein design concepts, computational modeling tools, high resolution and high-throughput experimental methods it is now possible to design new protein architectures. The collection of building blocks and design principles widened both in size and complexity, offering an expanded toolset for building new modular folds and functional protein structures. Here we review and discuss recent achievements of protein design, focusing in particular on the use and prospects of modular approaches for assembling new protein folds.
DOI：
10.1073/pnas.94.15.7698
发表时间：
1997-07-22
影响因子：
11.1
作者：
Gilbert, W;deSouza, SJ;Long, MY
通讯作者：
Long, MY
影响因子：
14.8
作者：
Huang PS;Feldmeier K;Parmeggiani F;Velasco DAF;Höcker B;Baker D
通讯作者：
Baker D
影响因子：
15
作者：
Craven TW;Cho MK;Traaseth NJ;Bonneau R;Kirshenbaum K
通讯作者：
Kirshenbaum K