Role of Beta-Adrenergic Mechanisms in Exercise Training-Induced Metabolic Changes in Respiratory and Locomotor Muscle
Role of Beta-Adrenergic Mechanisms in Exercise Training-Induced Metabolic Changes in Respiratory and Locomotor Muscle
复制标题
β-肾上腺素能机制在运动训练引起的呼吸肌和运动肌代谢变化中的作用
DOI：
10.1055/s-2007-972956
复制
发表时间：
1995
影响因子：
2.5
通讯作者：
Daniel Martín
中科院分区：
文献类型：
--
作者：
S. Powers;M. Wade;D. Criswell;R. A. Herb;S. Dodd;R. Hussain;Daniel Martín
为了验证这样一种假设，即运动训练后呼吸和运动骨骼肌氧化能力的正常增加需要β-肾上腺素能刺激，我们研究了β-受体阻滞剂对训练和久坐大鼠肌肉氧化能力的影响。成年雌性SD大鼠34只，随机分为4组：1)训练+心得安(TP)组；2)训练+假注射(TS)组；3)安静+心得安(SP)组；4)安静+假注射(SS)组。与SS动物相比，训练使TS动物足底(+29%)和肋隔肌(+12%)的柠檬酸合成酶(CS)活性增加(p<；0.05)。相反，与SS组相比，训练并没有(p>；0.05)增加TP动物的肋隔膜CS活性。此外，尽管与SP组相比，TP组的足底CS活性增加(p<；0.05)(+18%)，但训练诱导的肌肉CS活性的增加比观察到的TS动物低11%(p<；0.05)。总而言之，这些结果表明，β-肾上腺素能机制可能在正常训练诱导的呼吸和运动骨骼肌氧化能力增加中发挥作用。
To test the hypothesis that beta-adrenergic stimulation is required for the normal increase in oxidative capacity of respiratory and locomotor skeletal muscle in response to exercise training, we examined the effects of beta-blockade on muscle oxidative capacity in trained and sedentary rats. Thirty-four female adult Sprague-Dawley rats were randomly divided into four experimental groups: 1) trained+propranolol (TP); 2) trained + sham injection (TS); 3) sedentary + propranolol (SP); and 4) sedentary + sham injection (SS). Training increased (p < 0.05) citrate synthase (CS) activity in the plantaris (+29%) and costal diaphragm (+12%) of TS animals compared to SS animals. In contrast, training did not (p > 0.05) increase costal diaphragm CS activity in TP animals compared to the SS group. Further, although training increased (p < 0.05) plantaris CS activity in the TP group (+18%) compared to the SP group, the training-induced increase in muscle CS activity was 11% lower (p < 0.05) than observed in TS animals. Collectively, these results suggest that beta-adrenergic mechanisms may play a role in the normal training-induced increase in oxidative capacity in both respiratory and locomotor skeletal muscles.
有证据表明，cAMP 可以增加大鼠肌管中苹果酸脱氢酶和延胡索酸酶的水平。
DOI：
10.1152/ajpcell.1984.247.1.c33
发表时间：
1984
期刊：
The American journal of physiology
影响因子：
--
作者：
LawrenceJr,JC;Salsgiver,WJ
通讯作者：
Salsgiver,WJ
持续收缩活动和β-肾上腺素受体之间的相互作用在骨骼肌基因表达调节中的作用。
DOI：
10.1152/ajpcell.1989.256.3.c506
发表时间：
1989
期刊：
The American journal of physiology
影响因子：
--
作者：
Kraus,WE;Bernard,TS;Williams,RS
通讯作者：
Williams,RS