Be like water, my cells: cell plasticity and the art of transformation.
Be like water, my cells: cell plasticity and the art of transformation.
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DOI：
10.3389/fcell.2023.1272730
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发表时间：
2023
影响因子：
5.5
通讯作者：
Myant, Kevin B.
中科院分区：
文献类型：
--
作者：
Cammareri, Patrizia;Myant, Kevin B.
细胞可塑性定义了细胞在发育、组织动态平衡和再生过程中采用不同身份的能力。不同状态之间的动态波动，无论是在谱系内还是在谱系之间，都受到染色质可及性和基因表达变化的调节。当解除调控时，细胞的可塑性可以促进癌症的发生和发展。癌细胞具有明显的可塑性，这导致肿瘤内的表型和功能异质性以及对靶向治疗的抵抗力。正是由于这些原因，科学界对了解癌细胞可塑性的分子机制越来越感兴趣。这篇小型综述的目的是讨论与化生和上皮-间充质转化相关的细胞可塑性的不同例子，重点是治疗耐药。
Cellular plasticity defines the capacity of cells to adopt distinct identities during development, tissue homeostasis and regeneration. Dynamic fluctuations between different states, within or across lineages, are regulated by changes in chromatin accessibility and in gene expression. When deregulated, cellular plasticity can contribute to cancer initiation and progression. Cancer cells are remarkably plastic which contributes to phenotypic and functional heterogeneity within tumours as well as resistance to targeted therapies. It is for these reasons that the scientific community has become increasingly interested in understanding the molecular mechanisms governing cancer cell plasticity. The purpose of this mini-review is to discuss different examples of cellular plasticity associated with metaplasia and epithelial-mesenchymal transition with a focus on therapy resistance.
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