Symptom Presentation and Access to Medical Care in Patients With Postural Orthostatic Tachycardia Syndrome: Role of Sex.
Symptom Presentation and Access to Medical Care in Patients With Postural Orthostatic Tachycardia Syndrome: Role of Sex.
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DOI：
10.1016/j.cjco.2021.08.014
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Raj SR
中科院分区：
文献类型：
--
作者：
Bourne KM;Hall J;Stiles LE;Sheldon RS;Shibao CA;Okamoto LE;Garland EM;Gamboa AC;Peltier A;Diedrich A;Biaggioni I;Robertson D;Raj SR
体位性心动过速综合征（POTS）是一种慢性直立不耐受，主要影响育龄女性患者。性别差异在POTS中的作用还没有得到很好的理解。我们试图确定诊断为POTS的女性和男性患者在诊断、症状、合并症和治疗方面的性别差异。由Dysautonomia International（East Moriches，NY）和范德比尔特大学医学中心（纳什维尔，TN）合作设计了一项综合调查。患者通过Dysautonomia International的网站和社交媒体渠道招募。该调查通过一个安全的研究数据采集数据库在线提供。根据生物性别分析反应。连续变量表示为中位数（第25百分位数-第75百分位数），分类变量表示为受试者数量和比例。共有8919例患者报告了POTS的医生诊断，并被纳入本分析。大多数受访者为女性（93.7%）。女性和男性患者的误诊率相似（76.2% vs 74.9%，P = 0.5），诊断前就诊医生数量相似（5 [3-8] vs 5 [3-8]，P = 0.9）。尽管存在这些相似性，但女性患者的诊断延迟时间长于男性患者（1.50 [0.25-5.25]年vs 0.92 [0.08-2.91]年，P < 0.001）。尽管POTS患者主要为女性，但女性患者在诊断方面比男性患者面临更多挑战。提高对POTS的认识和认识可能有助于减少女性和男性患者的诊断挑战，并改善患有这种衰弱性疾病的个人的治疗和管理。
Postural orthostatic tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance that primarily impacts female patients of childbearing age. The role of sex differences in POTS is not well understood. We sought to identify sex differences in diagnosis, symptoms, comorbidities, and treatments in female and male patients diagnosed with POTS. A comprehensive survey was designed in partnership by Dysautonomia International (East Moriches, NY) and Vanderbilt University Medical Center (Nashville, TN). Patients were recruited through Dysautonomia International’s website and social media channels. The survey was delivered online through a secure research data capture database. Responses were analyzed according to biological sex. Continuous variables are presented as median (25th percentile-75th percentile), and categorical variables are presented as number and proportion of participants. A total of 8919 patients reported a physician diagnosis of POTS and were included in this analysis. The majority of respondents were female (93.7%). Female and male patients experienced misdiagnosis at similar rates (76.2% vs 74.9%, P = 0.5) and saw a similar number of doctors before diagnosis (5 [3-8] vs 5 [3-8], P = 0.9). Despite these similarities, diagnostic delay was longer for female, compared with male, patients (1.50 [0.25-5.25] years vs 0.92 [0.08-2.91] years, P < 0.001). Despite the primarily female demographic of POTS patients, female patients experience more challenges with diagnosis than male patients. Increased awareness and recognition of POTS may help to reduce the diagnostic challenges in both female and male patients, and improve treatment and management for individuals living with this debilitating disorder.
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影响因子：
4.8
作者：
McLean CP;Asnaani A;Litz BT;Hofmann SG
通讯作者：
Hofmann SG
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