Variation in the phase of response to low-frequency pure tones in the guinea pig auditory nerve as functions of stimulus level and frequency.
Variation in the phase of response to low-frequency pure tones in the guinea pig auditory nerve as functions of stimulus level and frequency.
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DOI：
10.1007/s10162-008-0151-x
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发表时间：
2009-06
影响因子：
2.4
通讯作者：
Shackleton, Trevor M.
中科院分区：
文献类型：
--
作者：
Palmer, Alan R.;Shackleton, Trevor M.
毛细胞刺激的方向性与基底膜的振动相结合，导致听神经纤维动作电位对低频刺激的反应出现在刺激波形的特定阶段。由于在耳蜗尖的直接机械测量是困难的，这种相位锁定经常被用来间接推断基底膜的运动。在这里，我们使用正弦波刺激在大范围的声级(高达90分贝的声压级)上证实和扩展了哺乳动物的早期数据。我们记录了麻醉豚鼠大量听神经纤维在广泛频率和声级范围内对纯音的锁相反应。结果表明，对于恒定的刺激频率，相位滞后随神经纤维特征频率的增加而减小。在高于刺激频率的Cf处，相位滞后减小，超过该值时，其减小速度要慢得多。这样的相位变化与已知的基本耳蜗力学是一致的。对单个纤维的测量显示，随着声级的变化，相位变化较小，但系统变化，证实了之前的报道。我们发现了一个“零”刺激频率，在该频率下，相位随声级的变化很小。该零频率通常不在CF处。当刺激频率低于零点时，声音水平存在递进滞后，高于零点的刺激频率存在递进超前现象。这最多是0.2个周期。
The directionality of hair cell stimulation combined with the vibration of the basilar membrane causes the auditory nerve fiber action potentials, in response to low-frequency stimuli, to occur at a particular phase of the stimulus waveform. Because direct mechanical measurements at the cochlear apex are difficult, such phase locking has often been used to indirectly infer the basilar membrane motion. Here, we confirm and extend earlier data from mammals using sine wave stimulation over a wide range of sound levels (up to 90 dB sound pressure level). We recorded phase-locked responses to pure tones over a wide range of frequencies and sound levels of a large population of auditory nerve fibers in the anesthetized guinea pig. The results indicate that, for a constant frequency of stimulation, the phase lag decreases with increases in the characteristic frequency (CF) of the nerve fiber. The phase lag decreases up to a CF above the stimulation frequency, beyond which it decreases at a much slower rate. Such phase changes are consistent with known basal cochlear mechanics. Measurements from individual fibers showed smaller but systematic variations in phase with sound level, confirming previous reports. We found a “null” stimulation frequency at which little variation in phase occurred with sound level. This null frequency was often not at the CF. At stimulation frequencies below the null, there was a progressive lag with sound level and a progressive lead for stimulation frequencies above the null. This was maximally 0.2 cycles.
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影响因子：
2.4
作者：
ALLEN, JB
通讯作者：
ALLEN, JB
影响因子：
2.8
作者：
CARNEY, LH
通讯作者：
CARNEY, LH
影响因子：
2.4
作者：
BUUNEN, TJF;RHODE, WS
通讯作者：
RHODE, WS
DOI：
10.1159/000095281
发表时间：
2006-01-01
期刊：
ORL-JOURNAL FOR OTO-RHINO-LARYNGOLOGY AND ITS RELATED SPECIALTIES
影响因子：
--
作者：
Cooper, Nigel P.
通讯作者：
Cooper, Nigel P.
影响因子：
5.5
作者：
EVANS, EF
通讯作者：
EVANS, EF