Pegylated Liposomal Doxorubicin in Vindesine-Based and Bortezomib-Based Regimens for Patients With Newly Diagnosed Multiple Myeloma: A Retrospective Study of Efficacy and Safety.
Pegylated Liposomal Doxorubicin in Vindesine-Based and Bortezomib-Based Regimens for Patients With Newly Diagnosed Multiple Myeloma: A Retrospective Study of Efficacy and Safety.
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聚乙二醇化脂质体多柔比星在基于长春地辛和硼替佐米的治疗方案中用于新诊断的多发性骨髓瘤患者：疗效和安全性的回顾性研究。
DOI：
10.3389/fonc.2021.597453
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发表时间：
2021
影响因子：
4.7
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Zhai Y;Yuan D;Ge X;Hu S;Li P;Fang X;Li Y;Zhou X;Wang X
尽管聚乙二醇化脂质体多柔比星（PLD）已被批准与硼替佐米联合治疗复发/难治性多发性骨髓瘤（MM），但PLD在不同方案下对新诊断多发性骨髓瘤（NDMM）患者的抗肿瘤疗效和耐受性尚未完全确定。这项回顾性研究纳入了2008年1月至2019年10月期间诊断的249例NDMM患者。其中，以长春地碱为基础的化疗112例（35 vDD, 77 vAD），以硼替佐米为基础的化疗137例（58 vDD, 79 VD）。在含硼替佐米方案中，VDD的完全缓解率（48.3% vs. 30.4%, p = 0.033）和非常好的部分缓解率（74.1 vs. 57.0%, p = 0.038）显著高于VD亚组。而VDD亚组和VD亚组之间没有更高的生存率。在含有长春地西的方案中，vDD和vAD在缓解率和生存率方面没有统计学意义。所有心脏ae的发生率在VDD和VD之间相似。vDD方案与vAD方案在NDMM患者的有效率、生存率和毒性方面相似。在VD的基础上添加PLD可以带来更深层次的反应，但没有增加毒性，但没有发现更高的生存期。
Although pegylated liposomal doxorubicin (PLD) has been approved in combination with bortezomib for relapsed/refractory multiple myeloma (MM), the antitumor efficacy and tolerability of PLD in different regimens for patients with newly diagnosed MM (NDMM) have not been fully defined. A total of 249 NDMM patients diagnosed between January 2008 and October 2019 were included in this retrospective study. Among them, 112 patients received vindesine-based chemotherapy (35 vDD and 77 vAD) and 137 received bortezomib-based chemotherapy (58 VDD and 79 VD). In bortezomib-containing regimens, the complete response rate (48.3 vs. 30.4%, p = 0.033) and very good partial response or better rate (74.1 vs. 57.0%, p = 0.038) of VDD were significantly higher than those of VD subgroup. While no superior survival was found between VDD and VD subgroup. In vindesine-containing regimens, no statistical significance was identified between vDD and vAD in terms of response rate and survival. The occurrence rates of all cardiac AEs were similar between VDD and VD. The vDD regimen was similar with vAD in the aspect of response rate, survival, and toxicity in NDMM patients. The addition of PLD to VD brought deeper response without increased toxicity, while no superior survival was found.
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影响因子：
28.5
作者：
Liu, Jiangmei;Liu, Weiping;Wang, Lijun
通讯作者：
Wang, Lijun
影响因子：
45.3
作者：
Jakubowiak, Andrzej J.;Kendall, Tara;Kaminski, Mark S.
通讯作者：
Kaminski, Mark S.
影响因子：
3.1
作者：
Nishihori, Taiga;Baz, Rachid;Alsina, Melissa
通讯作者：
Alsina, Melissa
影响因子：
6.2
作者：
Orlowski RZ;Nagler A;Sonneveld P;Bladé J;Hajek R;Spencer A;Robak T;Dmoszynska A;Horvath N;Spicka I;Sutherland HJ;Suvorov AN;Xiu L;Cakana A;Parekh T;San-Miguel JF
通讯作者：
San-Miguel JF
影响因子：
20.3
作者：
Mitsiades, N;Mitsiades, CS;Anderson, KC
通讯作者：
Anderson, KC