High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote.
High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote.
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高速导轨模型揭示了由真核生物中短反复序列介导的基因串联放大。
DOI：
10.1038/s41598-022-06250-3
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发表时间：
2022-02-10
影响因子：
4.6
通讯作者：
Deng C
中科院分区：
文献类型：
--
作者：
Chen H;Xue J;Zhang Z;Zhang G;Xu X;Li H;Zhang R;Ullah N;Chen L;Amanullah;Zang Z;Lai S;He X;Li W;Guan M;Li J;Chen L;Deng C
基因复制/扩增(GDA)的发生为环境胁迫下的适应性进化提供了潜在的材料。已经提出了几种分子模型来解释GDA，通过短时间的序列相似性进行重组起着至关重要的作用。通过对这类事件的基因组筛选，我们提出了一个“短重复序列(Short Repeat Sequence)*N + 单位 + SRS*N”的不等姐妹染色单体交换(USCE)扩增单位，用于真核生物中不同重复数的短重复序列介导的串联扩增。从2131个组织良好的扩增事件中鉴定出的扩增单位，这些扩增事件产生了多个基因/元素拷贝，并在相应物种中随后进行了适应性进化。我们分析的基因组数据显示了不同生态型/品系的相关种或亚种或植物之间的动态变化。本研究阐明了在USCE机制下扩增单位两侧的可变拷贝数SRS的特征，以解释在环境胁迫下SRS介导的在所有真核生物中组织良好的基因串联扩增。
The occurrence of gene duplication/amplification (GDA) provide potential material for adaptive evolution with environmental stress. Several molecular models have been proposed to explain GDA, recombination via short stretches of sequence similarity plays a crucial role. By screening genomes for such events, we propose a “SRS (short repeated sequence) *N + unit + SRS*N” amplified unit under USCE (unequal sister-chromatid exchange) for tandem amplification mediated by SRS with different repeat numbers in eukaryotes. The amplified units identified from 2131 well-organized amplification events that generate multi gene/element copy amplified with subsequent adaptive evolution in the respective species. Genomic data we analyzed showed dynamic changes among related species or subspecies or plants from different ecotypes/strains. This study clarifies the characteristics of variable copy number SRS on both sides of amplified unit under USCE mechanism, to explain well-organized gene tandem amplification under environmental stress mediated by SRS in all eukaryotes.
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影响因子：
64.8
作者：
Gan X;Stegle O;Behr J;Steffen JG;Drewe P;Hildebrand KL;Lyngsoe R;Schultheiss SJ;Osborne EJ;Sreedharan VT;Kahles A;Bohnert R;Jean G;Derwent P;Kersey P;Belfield EJ;Harberd NP;Kemen E;Toomajian C;Kover PX;Clark RM;Rätsch G;Mott R
通讯作者：
Mott R
影响因子：
64.8
作者：
HARBERS, K;SORIANO, P;JAENISCH, R
通讯作者：
JAENISCH, R
DOI：
10.1073/pnas.0603796103
发表时间：
2006-07-05
影响因子：
11.1
作者：
Cheng, Chi-Hing C.;Cziko, Paul A.;Evans, Clive W.
通讯作者：
Evans, Clive W.
影响因子：
14.9
作者：
Letunic, Ivica;Bork, Peer
通讯作者：
Bork, Peer
影响因子：
3.9
作者：
Berna, Luisa;Rodriguez, Matias;Robello, Carlos
通讯作者：
Robello, Carlos