Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis.
Sphingosine 1-Phosphate (S1P) in the Peritoneal Fluid Skews M2 Macrophage and Contributes to the Development of Endometriosis.
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DOI：
10.3390/biomedicines9111519
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发表时间：
2021-10-22
期刊：
影响因子：
4.7
通讯作者：
Hirata S
中科院分区：
文献类型：
--
作者：
Ono Y;Kawakita T;Yoshino O;Sato E;Kano K;Ohba M;Okuno T;Ito M;Koga K;Honda M;Furue A;Hiraoka T;Wada S;Iwasa T;Yokomizo T;Aoki J;Maeda N;Unno N;Osuga Y;Hirata S
1-磷酸鞘氨醇（S1 P）是一种炎症介质，大量存在于红细胞和血小板中。我们假设，在腹腔中的S1 P浓度会增加，特别是在月经期，由于经血的回流，并调查了14个非子宫内膜异位症和19个子宫内膜异位症患者的人腹腔液（PF）中的S1 P浓度。虽然样本数量相对较少，在解释结果时需要谨慎，但与非月经期相比，月经期PF中的S1 P浓度主要增加，无论是否存在子宫内膜异位症。在非月经期，子宫内膜异位症患者与对照组相比，S1 P浓度显着增加。使用人腹膜内巨噬细胞（MΦ）的体外实验显示，S1 P刺激使它们偏向M2 M Φ-优势条件，并增加IL-6和考克斯-2的表达。一项体内研究表明，在子宫内膜异位症小鼠模型中，S1 P的给药增加了子宫内膜样病变的大小。
Sphingosine 1-phosphate (S1P), an inflammatory mediator, is abundantly contained in red blood cells and platelets. We hypothesized that the S1P concentration in the peritoneal cavity would increase especially during the menstrual phase due to the reflux of menstrual blood, and investigated the S1P concentration in the human peritoneal fluid (PF) from 14 non-endometriosis and 19 endometriosis patients. Although the relatively small number of samples requires caution in interpreting the results, S1P concentration in the PF during the menstrual phase was predominantly increased compared to the non-menstrual phase, regardless of the presence or absence of endometriosis. During the non-menstrual phase, patients with endometriosis showed a significant increase in S1P concentration compared to controls. In vitro experiments using human intra-peritoneal macrophages (MΦ) showed that S1P stimulation biased them toward an M2MΦ-dominant condition and increased the expression of IL-6 and COX-2. An in vivo study showed that administration of S1P increased the size of the endometriotic-like lesion in a mouse model of endometriosis.
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