Alterations of Intrinsic Connectivity Networks in Antipsychotic-Naïve First-Episode Schizophrenia.
Alterations of Intrinsic Connectivity Networks in Antipsychotic-Naïve First-Episode Schizophrenia.
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抗精神病药 - 不依次的第一集精神分裂症中固有连通性网络的改变。
DOI：
10.1093/schbul/sbx171
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发表时间：
2018-10-17
影响因子：
6.6
通讯作者：
Rostrup E
中科院分区：
文献类型：
--
作者：
Anhøj S;Ødegaard Nielsen M;Jensen MH;Ford K;Fagerlund B;Williamson P;Glenthøj B;Rostrup E
对antipsychotic-naïve首发精神分裂症的大规模内在连接网络的研究增加了我们对精神分裂症系统级脑功能障碍的理解，同时使我们能够控制药物和疾病进展的混杂效应。关于antipsychotic-naïve患者功能连通性的报告一直是混杂的，网络改变、精神病理和认知之间的关系尚不清楚。在静息条件下，对47例未接受过抗精神病药物治疗的首发精神分裂症患者和47例健康对照者进行了功能磁共振成像扫描。主要观察指标为组间功能连通性的差异以及网络改变、精神病理和认知之间的关系。右侧中央执行网络（CEN）与右侧腹侧注意网络（VAN）（患者>对照，P = 0.001）、左侧中央执行网络与左侧腹侧注意网络（P = 0.002）、后置默认模式网络与听觉网络（P = 0.006）之间的连连性发生改变。网络连通性与临床特征之间存在相关性，实验组与持续注意的效果之间存在交互作用（P = 0.005），实验组与处理速度之间存在交互作用（P = 0.007），影响右侧CEN和右侧VAN之间的连通性。我们的研究结果表明，精神分裂症早期阶段的特征是前额-顶叶网络之间的连通性增加，这可能与认知和感觉功能的控制有关。此外，目前的研究表明，不脱离VAN的问题会导致注意力和可能的主观意识困难。
The investigation of large-scale intrinsic connectivity networks in antipsychotic-naïve first-episode schizophrenia increases our understanding of system-level cerebral dysfunction in schizophrenia while enabling control of confounding effects of medication and disease progression. Reports on functional connectivity in antipsychotic-naïve patients have been mixed and the relation between network alterations, psychopathology and cognition is unclear. A total number of 47 patients with first-episode schizophrenia who had never received antipsychotic medication and 47 healthy controls were scanned with functional magnetic resonance imaging under resting conditions. Main outcome measures were differences in functional connectivity between groups and the relationship between network alterations, psychopathology and cognition. Altered connectivity was found between right central executive network (CEN) and right ventral attention network (VAN) (patients > controls, P = .001), left CEN and left VAN (P = .002), and between posterior default mode network and auditory network (P = .006). Association between network connectivity and clinical characteristics was found as interactions between the effects of group and sustained attention (P = .005) and between group and processing speed (P = .007) on the connectivity between right CEN and right VAN. Our findings suggest that the early phase of schizophrenia is characterized by increased connectivity between fronto-parietal networks suggested to be involved in the control of cognitive and sensory functions. Moreover, the present study suggests that the problem of not disengaging the VAN leads to difficulties with attention and possibly subjective awareness.
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发表时间：
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影响因子：
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