Surgery improves survival in bladder signet-ring cell carcinoma-a population-based study.
Surgery improves survival in bladder signet-ring cell carcinoma-a population-based study.
复制标题
DOI：
10.1177/17562872221079473
复制
发表时间：
2022-01
影响因子：
2
通讯作者：
Li, Xiancheng
中科院分区：
文献类型：
--
作者：
Alradhi, Mohammed;Safi, Mohammed;Tao, Shenghua;Al-danakh, Abdullah;Almoiliqy, Marwan;Baldi, Salem;Li, Xiancheng
本研究旨在探讨膀胱印戒细胞癌(SRCC)患者的手术治疗价值。手术并未被视为膀胱癌(SRCC)的预后因素。使用监测、流行病学和最终结果计划(SEER)，1975年至2018年报告的膀胱SRCC患者被纳入一项回顾研究。采用单因素和多因素COX回归模型分析手术治疗对病因特异性生存率(CS)和总生存率(OS)的影响。我们将595例SRCC患者分为两组：496例接受手术治疗；99例未接受手术治疗。两组病例均以男性为主(p = 0.04)。大多数接受手术的患者(77.2vs58.6vs58.6vs58.6p ⩽ 0.001)和没有保险的患者(p ⩽ 0.001)观察到中、低分化(III-IV)。在多因素COX比例风险模型(危险比[HR]=0.001)中调整年龄、种族、性别、原发部位、分级、分期、淋巴结清扫、化疗记录、放疗记录、保险、婚姻状况等变量后，采用KM检验，手术组的OS和Css显著优于非手术组(p = 0.001，%)。95%可信区间[CI] = 0.449-0.782；p = 0.0001)。与化疗和放疗相比，手术显著改善了膀胱SRCC的生存结果。化疗和放疗导致生存率较低。建立了诺模图预测模型，其中OS预测的C指数为0.70，CS预测的C指数为73。OS的AUC分别为0.77、0.76和0.74，而CS的AUC分别为0.83、0.80和0.79。手术是膀胱SRCC存活率的重要独立预测因素。接受手术的患者比未接受手术的患者有更高的CS和OS。手术也比不同治疗方式的组合带来了更好的存活率。
The purpose of this study is to determine the therapeutic value of surgery in individuals with urinary bladder signet ring cell carcinoma (SRCC). Surgery has not been examined as a prognostic factor for urinary bladder cancer (SRCC). Using the Surveillance, Epidemiology, and End Results program (SEER), patients with urinary bladder SRCC who presented from 1975 to 2018 were included in a retrospective study. The effect of surgical therapy on cause-specific survival (CSS) and overall survival (OS) was examined using univariate and multivariate Cox regression models. We subdivided 595 patients with SRCC into 2 groups, as follows: 496 who underwent surgery; and 99 who did not undergo surgery. Males had high predominance in all cases in both groups (p = 0.04). Moderate and poor differentiation (III–IV) were observed in the majority of patients who underwent surgery (77.2 vs 58.6, p ⩽ 0.001) and had no insurance (p ⩽ 0.001). By using KM, the OS and CSS of the surgery group were found to be significantly better than those of the non-surgery group (p = 0.001,%) after adjusting for the variables of age, race, sex, primary site, grade, stage, lymph node removal, chemotherapy record, radiotherapy record, insurance, and marital status in the multivariate Cox proportional hazard model (hazard ratio [HR]= 0. 592; 95% confidence interval [CI] = 0.449–0.782; p = 0.0001). In comparison with chemotherapy and radiation, which resulted in poorer survival rates, surgery considerably improved survival outcomes in urinary bladder SRCC. The nomogram prediction model was built with C-index values of 0.70 and 73 for OS and CSS prediction, respectively. AUC in OS values were 0.77, 0.76, and 0.74, whereas AUC in CSS were 0.83, 0.80, and 0.79 for the 1-, 3-, and 5-year survival nomograms, respectively. Surgery was a significant independent predictor of bladder SRCC survival. Patients who underwent surgery had higher CSS and OS than people who did not undergo surgery. Surgery also led to better survival than the combination of the different treatment modalities.
登录
查看更多内容
影响因子：
5.2
作者：
Figueiredo J;Mercadillo F;Melo S;Barroso A;Gonçalves M;Díaz-Tasende J;Carneiro P;Robles L;Colina F;Ibarrola C;Perea J;Morais-de-Sá E;Seruca R;Urioste M
通讯作者：
Urioste M
影响因子：
5.6
作者：
Hartman, Douglas J.;Nikiforova, Marina N.;Pai, Reetesh K.
通讯作者：
Pai, Reetesh K.
DOI：
10.1097/coc.0000000000000704
发表时间：
2020-08-01
影响因子：
2.6
作者：
Luzzago, Stefano;Palumbo, Carlotta;Karakiewicz, Pierre, I
通讯作者：
Karakiewicz, Pierre, I
影响因子：
3
作者：
Lee, Won-Suk;Chun, Ho-Kyung;Song, Sang Yong
通讯作者：
Song, Sang Yong
影响因子：
2.5
作者：
Fu, Jianfei;Wu, Lunpo;Du, Jinlin
通讯作者：
Du, Jinlin