Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase.
Low levels of the omega-3 index are associated with sudden cardiac arrest and remain stable in survivors in the subacute phase.
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DOI：
10.1007/s11745-010-3511-3
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发表时间：
2011-02
期刊：
影响因子：
1.9
通讯作者：
Nilsen DW
中科院分区：
文献类型：
--
作者：
Aarsetoey H;Aarsetoey R;Lindner T;Staines H;Harris WS;Nilsen DW
在以往的研究中，低血n-3脂肪酸水平与心源性死亡风险的增加有关，而omega-3指数(红细胞(RBC)二十碳五烯酸(EPA)和二十二碳六烯酸(DHA)占FA总量的百分比)最近被认为是冠心病死亡的新危险因素，特别是在心脏骤停(SCA)之后。由于血液样本通常是在事件发生后采集的，我们研究的目的是评估SCA后红细胞脂肪酸的稳定性。对25例院外心脏骤停幸存者、15例无SCA的心肌梗死患者和5例健康受试者在前48小时内测量了包括omega-3指数在内的总FA谱三次。我们不能显示在任何组的FA测量的显著变化，这也适用于omega-6/omega-3比率和花生四烯酸(AA)/EPA比率。此外，我们比较了14例首次心肌梗死患者和185例首次心肌梗死患者的omega-3指数，平均值分别为4.59%和6.48%(p=0.002)。在多变量Logistic回归分析中，omega-3指数每增加1%与室颤风险降低58%(95%可信区间：0.25-0.76%)相关。总而言之，在SCA事件后，omega-3指数保持稳定，并预测了VF的风险。
In previous studies, low blood levels of n-3 fatty acids (FA) have been associated with increased risk of cardiac death, and the omega-3 index (red blood cell (RBC) eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) expressed as weight percentage of total FA) has recently been proposed as a new risk factor for death from coronary artery disease, especially following sudden cardiac arrest (SCA). As blood samples often haven been harvested after the event, the aim of our study was to evaluate the stability of RBC fatty acids following SCA. The total FA profile, including the omega-3 index, was measured three times during the first 48 h in 25 survivors of out-of-hospital cardiac arrest (OHCA), in 15 patients with a myocardial infarction (MI) without SCA and in 5 healthy subjects. We could not demonstrate significant changes in the FA measurements in any of the groups, this also applied to the omega-6/omega-3 ratio and the arachidonic acid (AA)/EPA ratio. Furthermore, we compared the omega-3 index in 14 OHCA-patients suffering their first MI with that of 185 first-time MI-patients without SCA; mean values being 4.59% and 6.48%, respectively (p = 0.002). In a multivariate logistic regression analysis, a 1% increase of the omega-3 index was associated with a 58% (95% CI: 0.25–0.76%) reduction in risk of ventricular fibrillation (VF). In conclusion, the omega-3 index remained stable after an event of SCA and predicted the risk of VF.
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DOI：
10.1016/j.bbrc.2004.06.114
发表时间：
2004-08-11
影响因子：
3.1
作者：
Xiao, YF;Ke, QH;Leaf, A
通讯作者：
Leaf, A
影响因子：
158.5
作者：
Albert, CM;Campos, H;Ma, J
通讯作者：
Ma, J
影响因子：
6.5
作者：
Grubb, NR;Fox, KAA;Cawood, P
通讯作者：
Cawood, P
影响因子：
4.2
作者：
Aarsetoey, Hildegunn;Ponitz, Volker;Nilsen, Dennis W. T.
通讯作者：
Nilsen, Dennis W. T.
影响因子：
7.2
作者：
KARK, JD;MANOR, O;BERRY, EM
通讯作者：
BERRY, EM