The influence of type-specific human papillomavirus infections on the detection of cervical precancer and cancer: A population-based study of opportunistic cervical screening in the United States.
The influence of type-specific human papillomavirus infections on the detection of cervical precancer and cancer: A population-based study of opportunistic cervical screening in the United States.
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DOI：
10.1002/ijc.28605
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发表时间：
2014-08-01
影响因子：
6.4
通讯作者：
Castle, Philip E.
中科院分区：
文献类型：
--
作者：
Wheeler, Cosette M.;Hunt, William C.;Cuzick, Jack;Langsfeld, Erika;Robertson, Michael;Castle, Philip E.
关键词：
在美国（US）人群中检测宫颈癌前病变和癌症的预期风险数据有限，特别是在管理式护理之外和没有有组织的国家计划的情况下进行机会性宫颈筛查。这些数据将为广泛接种人乳头瘤病毒（HPV）疫苗前后筛查结果呈阳性的妇女的管理提供信息，并在美国宫颈癌筛查指南最近发生变化之前建立基线。利用向新墨西哥州HPV Pap登记处的全州被动监测系统报告的数据，我们测量了在各种组织、付款人、临床环境、提供者和患者的真实世界医疗保健提供期间检测到的2级或更严重（CIN2+）和3级或更严重（CIN3+）的3年HPV类型特异性累积发病率。从379，000名妇女的筛查人群中分层抽取47，541份宫颈细胞学标本进行HPV基因分型。细胞学诊断和HPV风险组的不同组合的三年风险范围为<1%（对于几种组合），在高级别（HSIL）细胞学和HPV 16感染的女性中，CIN2+约为70%，CIN3+约为55%。相当比例的CIN2+（35.7%）和CIN3+（30.9%）在细胞学阴性后被诊断，其中高危型HPV阳性分别为62.3%和78.2%。HPV16的3年发病率最高（CIN 2+为10.9%，CIN 3+为8.0%），其次为HPV33、HPV31和HPV18。高危型HPV阳性结果，尤其是HPV16，细胞学解释的严重程度和年龄独立地影响CIN2+和CIN3+的风险。
There are limited data on the prospective risks of detecting cervical precancer and cancer in United States (US) populations specifically where the delivery of opportunistic cervical screening takes place outside managed care and in the absence of organized national programs. Such data will inform the management of women with positive screening results before and after widespread human papillomavirus (HPV) vaccination and establishes a baseline preceding recent changes in US cervical cancer screening guidelines. Using data reported to the statewide passive surveillance systems of the New Mexico HPV Pap Registry, we measured the 3-year HPV type-specific cumulative incidence of cervical intraepithelial neoplasia grade 2 or more severe (CIN2+) and grade 3 or more severe (CIN3+) detected during real-world health care delivery across a diversity of organizations, payers, clinical settings, providers and patients. A stratified sample of 47,541 cervical cytology specimens from a screening population of 379,000 women underwent HPV genotyping. Three-year risks for different combinations of cytologic interpretation and HPV risk group ranged from <1% (for several combinations) to approximately 70% for CIN2+ and 55% for CIN3+ in women with high-grade (HSIL) cytology and HPV16 infection. A substantial proportion of CIN2+ (35.7%) and CIN3+ (30.9%) were diagnosed following negative cytology, of which 62.3 and 78.2%, respectively, were high-risk HPV positive. HPV16 had the greatest 3-year risks (10.9% for CIN2+,8.0% for CIN3+) followed by HPV33, HPV31, and HPV18. Positive results for high-risk HPV, especially HPV16, the severity of cytologic interpretation, and age contribute independently to the risks of CIN2+ and CIN3+.
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影响因子：
51.1
作者：
de Sanjose, Silvia;Quint, Wim G. V.;Xavier Bosch, F.
通讯作者：
Xavier Bosch, F.
影响因子：
9.4
作者：
Castle, Philip E.;Gravitt, Patti E.;Schiffman, Mark
通讯作者：
Schiffman, Mark
影响因子：
6.4
作者：
Wheeler, Cosette M.;Hunt, William C.;Cuzick, Jack;Langsfeld, Erika;Pearse, Amanda;Montoya, George D.;Robertson, Michael;Shearman, Catherine A.;Castle, Philip E.
通讯作者：
Castle, Philip E.
DOI：
10.1073/pnas.80.12.3812
发表时间：
1983-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
DURST, M;GISSMANN, L;ZURHAUSEN, H
通讯作者：
ZURHAUSEN, H
影响因子：
11.2
作者：
Safaeian M;Schiffman M;Gage J;Solomon D;Wheeler CM;Castle PE
通讯作者：
Castle PE