Fibro-Adipogenic Progenitors: Versatile keepers of skeletal muscle homeostasis, beyond the response to myotrauma.
Fibro-Adipogenic Progenitors: Versatile keepers of skeletal muscle homeostasis, beyond the response to myotrauma.
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DOI：
10.1016/j.semcdb.2021.07.013
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发表时间：
2021-11
影响因子：
7.3
通讯作者：
Puri PL
中科院分区：
文献类型：
--
作者：
Wei X;Nicoletti C;Puri PL
虽然纤维脂肪生成祖细胞（FAP）最初被确定为响应肌肉损伤而激活的肌肉间质间充质细胞，并具有诱导性纤维生成和脂肪生成潜力，但随后的研究扩大了它们的表型和功能库，并揭示了它们对骨骼肌的贡献对广泛的干扰的反应。在这里，我们回顾了FAP对骨骼肌对运动神经元损伤和全身生理（例如，运动）或病理代谢（例如，糖尿病）的干扰。我们还提供了一个初始蓝图的离散子集群的FAPs，激活特定的扰动，并讨论它们在肌肉适应这些条件的作用。
While Fibro-Adipogenic Progenitors (FAPs) have been originally identified as muscle-interstitial mesenchymal cells activated in response to muscle injury and endowed with inducible fibrogenic and adipogenic potential, subsequent studies have expanded their phenotypic and functional repertoire and revealed their contribution to skeletal muscle response to a vast range of perturbations. Here we review the emerging contribution of FAPs to skeletal muscle responses to motor neuron injuries and to systemic physiological (e.g., exercise) or pathological metabolic (e.g., diabetes) perturbations. We also provide an initial blueprint of discrete sub-clusters of FAPs that are activated by specific perturbations and discuss their role in muscle adaptation to these conditions.
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影响因子：
8.8
作者：
Carnio S;LoVerso F;Baraibar MA;Longa E;Khan MM;Maffei M;Reischl M;Canepari M;Loefler S;Kern H;Blaauw B;Friguet B;Bottinelli R;Rudolf R;Sandri M
通讯作者：
Sandri M
DOI：
10.1016/j.biocel.2014.04.025
发表时间：
2014-08-01
影响因子：
4
作者：
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通讯作者：
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作者：
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通讯作者：
Feige JN
影响因子：
4.8
作者：
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通讯作者：
Zhang, Liping
影响因子：
4.6
作者：
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通讯作者：
De Lisio, Michael