Study of matrix metalloproteinases and their inhibitors in prostate cancer.
Study of matrix metalloproteinases and their inhibitors in prostate cancer.
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DOI：
10.1038/sj.bjc.6605569
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发表时间：
2010-03-02
影响因子：
8.8
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中科院分区：
文献类型：
--
作者：
细胞外基质金属蛋白酶（extracellular matrix metalloproteins，MMPs）由于其在基底膜和细胞外基质降解中的潜在作用，从而促进肿瘤的侵袭和转移，在肿瘤研究中引起了极大的兴趣。使用组织阵列和针对MMPs 1、2、7、9、11、13、14及其组织抑制剂TIMPs 1、2和3的特异性抗体进行免疫组织化学研究。对133例临床局限性前列腺癌患者、20例前列腺上皮内瘤变患者和50例良性前列腺增生患者和对照组的癌症标本进行了2600多次测定。与良性病变相比，前列腺癌有更高的表达所有MMPs和TIMPs。Dendogram显示肿瘤一级分为两种不同的MMPs/TIMPs分子谱，其中一种具有高MMPs/TIMs表达谱（n=70; 52.6%）。MMP-11或-13或其簇的高表达的肿瘤与较高的生化复发概率显著相关。MMPs和TIMPs的表达似乎在前列腺癌的分子生物学中具有重要作用，并且它们在肿瘤中的表达可能具有临床意义，可用作肿瘤侵袭性的指标。
Extracellular matrix metalloproteases (MMPs) have raised an extraordinary interest in cancer research because of their potential role in basal membrane and extracellular matrix degradation, consequently facilitating tumour invasion and metastases development. An immunohistochemical study was performed using tissue arrays and specific antibodies against MMPs 1, 2, 7, 9, 11, 13, 14, and their tissue inhibitors, TIMPs 1, 2 and 3. More than 2600 determinations on cancer specimens from 133 patients with clinically localised prostate carcinoma, 20 patients with prostatic intraepithelial neoplasia and 50 patients with benign prostate hyperplasia and controls, were performed. When compared with benign pathologies, prostate carcinomas had higher expression of all MMPs and TIMPs. Dendogram shows a first-order division of tumours into two distinct MMPs/TIMPs molecular profiles, one of them with high MMPs/TIMs expression profile (n=70; 52.6%). Tumours with high expression of MMP-11 or -13, or cluster thereof, were significantly associated with higher probability of biochemical recurrence. The expression of MMPs and TIMPs seems to have an important role in the molecular biology of prostate carcinomas, and their expression by tumours may be of clinical interest to used as indicators of tumour aggressiveness.
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影响因子：
4.8
作者：
Daja, MM;Niu, X;Russell, PJ
通讯作者：
Russell, PJ
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4.8
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Fingleton, B;Vargo-Gogola, T;Matrisian, LM
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Matrisian, LM
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影响因子：
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Ree, AH
影响因子：
4.8
作者：
Brehmer, B;Biesterfeld, S;Jakse, G
通讯作者：
Jakse, G