Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities.
Hypoxia as a Double-Edged Sword to Combat Obesity and Comorbidities.
复制标题
缺氧是对抗肥胖和合并症的双刃剑。
DOI：
10.3390/cells11233735
复制
发表时间：
2022-11-23
期刊：
影响因子：
6
通讯作者：
Wang, Ru
中科院分区：
文献类型：
--
作者：
Wang, Ruwen;Sun, Qin;Wu, Xianmin;Zhang, Yiyin;Xing, Xiaorui;Lin, Kaiqing;Feng, Yue;Wang, Mingqi;Wang, Yibing;Wang, Ru
The global epidemic of obesity is tightly associated with numerous comorbidities, such as type II diabetes, cardiovascular diseases and the metabolic syndrome. Among the key features of obesity, some studies have suggested the abnormal expansion of adipose-tissue-induced local endogenous hypoxic, while other studies indicated endogenous hyperoxia as the opposite trend. Endogenous hypoxic aggravates dysfunction in adipose tissue and stimulates secretion of inflammatory molecules, which contribute to obesity. In contrast, hypoxic exposure combined with training effectively generate exogenous hypoxic to reduce body weight and downregulate metabolic risks. The (patho)physiological effects in adipose tissue are distinct from those of endogenous hypoxic. We critically assess the latest advances on the molecular mediators of endogenous hypoxic that regulate the dysfunction in adipose tissue. Subsequently we propose potential therapeutic targets in adipose tissues and the small molecules that may reverse the detrimental effect of local endogenous hypoxic. More importantly, we discuss alterations of metabolic pathways in adipose tissue and the metabolic benefits brought by hypoxic exercise. In terms of therapeutic intervention, numerous approaches have been developed to treat obesity, nevertheless durability and safety remain the major concern. Thus, a combination of the therapies that suppress endogenous hypoxic with exercise plans that augment exogenous hypoxic may accelerate the development of more effective and durable medications to treat obesity and comorbidities.
登录
查看更多内容
影响因子：
3.9
作者：
Ahmad, Bilal;Vohra, Muhammad Sufyan;Wong, Eng Hwa
通讯作者：
Wong, Eng Hwa
cAMP-PKA 通路在乳酸诱导的小鼠肌内甘油三酯积累和线粒体含量增加中的作用
影响因子：
4
作者：
Chen S;Zhou L;Sun J;Qu Y;Chen M
通讯作者：
Chen M
影响因子：
16.6
作者：
通讯作者：
--
影响因子：
7.3
作者：
Babaei, Rohollah;Schuster, Maximilian;Vegiopoulos, Alexandros
通讯作者：
Vegiopoulos, Alexandros
DOI：
10.1016/j.bbrc.2015.04.020
发表时间：
2015-05-29
影响因子：
3.1
作者：
Bhattacharya, Indranil;Dominguez, Ana Perez;Battegay, Edouard J.
通讯作者：
Battegay, Edouard J.