Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer.
Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer.
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DOI：
10.1111/febs.13250
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Nebreda AR
中科院分区：
文献类型：
--
作者：
Gupta J;Nebreda AR
p38α丝裂原活化蛋白激酶通路不仅调节炎症介质的产生，而且还控制与组织稳态相关的过程，如细胞增殖、分化和存活，这些过程在恶性转化期间经常被破坏。这种信号通路的多功能性允许根据细胞类型和环境调节许多特定功能。在这里，我们讨论了小鼠模型，已被用来确定在体内功能的p38α信号在炎症性疾病和癌症的发病机制。使用转基因小鼠和药理学抑制剂的实验支持靶向p38α通路可能对某些炎性疾病和肿瘤类型有治疗作用。
The p38α mitogen‐activated protein kinase pathway not only regulates the production of inflammatory mediators, but also controls processes related to tissue homeostasis, such as cell proliferation, differentiation and survival, which are often disrupted during malignant transformation. The versatility of this signaling pathway allows for the regulation of many specific functions depending on the cell type and context. Here, we discuss mouse models that have been used to identify in vivo functions of p38α signaling in the pathogenesis of inflammatory diseases and cancer. Experiments using genetically modified mice and pharmacological inhibitors support that targeting the p38α pathway could be therapeutically useful for some inflammatory diseases and tumor types.
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