In vitro and in vivo models of non-alcoholic fatty liver disease (NAFLD).
In vitro and in vivo models of non-alcoholic fatty liver disease (NAFLD).
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DOI：
10.3390/ijms140611963
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发表时间：
2013-06-05
影响因子：
5.6
通讯作者：
Bergheim I
中科院分区：
文献类型：
--
作者：
Kanuri G;Bergheim I
目前，非酒精性脂肪性肝病（NAFLD）被认为是世界范围内最常见的肝脏疾病之一。NAFLD包括广泛的病理状况，从简单的脂肪变性到脂肪性肝炎、纤维化，最后甚至肝硬化；然而，只有少数患者进展到疾病的终末期，并且疾病进展到晚期的过程似乎很慢，在几年内逐渐发展。近年来已确定的主要危险因素包括超重、胰岛素抵抗、久坐不动的生活方式和改变的饮食模式，以及遗传因素和肠屏障功能紊乱。尽管密集的研究努力导致这些危险因素的识别，关于疾病的起源和参与进展的分子机制的知识仍然有限。本文综述了近年来常用的饮食诱导和遗传动物模型以及细胞培养模型，以加深对NAFLD相关机制的理解，并介绍了它们的优缺点。
By now, non-alcoholic fatty liver disease (NAFLD) is considered to be among the most common liver diseases world-wide. NAFLD encompasses a broad spectrum of pathological conditions ranging from simple steatosis to steatohepatitis, fibrosis and finally even cirrhosis; however, only a minority of patients progress to end-stages of the disease, and the course of the disease progression to the later stages seems to be slow, developing progressively over several years. Key risk factors including overweight, insulin resistance, a sedentary life-style and an altered dietary pattern, as well as genetic factors and disturbances of the intestinal barrier function have been identified in recent years. Despite intense research efforts that lead to the identification of these risk factors, knowledge about disease initiation and molecular mechanisms involved in progression is still limited. This review summarizes diet-induced and genetic animal models, as well as cell culture models commonly used in recent years to add to the understanding of the mechanisms involved in NAFLD, also referring to their advantages and disadvantages.
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DOI：
10.1152/ajpgi.00145.2011
发表时间：
2011-11-01
影响因子：
4.5
作者：
Charlton, Michael;Krishnan, Anuradha;Gores, Gregory
通讯作者：
Gores, Gregory
DOI：
10.1186/1476-9255-7-15
发表时间：
2010-03-30
期刊：
Journal of inflammation (London, England)
影响因子：
--
作者：
Harte AL;da Silva NF;Creely SJ;McGee KC;Billyard T;Youssef-Elabd EM;Tripathi G;Ashour E;Abdalla MS;Sharada HM;Amin AI;Burt AD;Kumar S;Day CP;McTernan PG
通讯作者：
McTernan PG
人类脂肪肝病：旧问题和新见解。
DOI：
10.1126/science.1204265
发表时间：
2011-06-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Cohen JC;Horton JD;Hobbs HH
通讯作者：
Hobbs HH
影响因子：
8.3
作者：
Ackerman, Z;Oron-Herman, M;Sela, BA
通讯作者：
Sela, BA
影响因子：
25.7
作者：
Bergheim, Ina;Weber, Synia;Bischoff, Stephan C.
通讯作者：
Bischoff, Stephan C.