Conjugated linoleic acid increased C-reactive protein in human subjects
Conjugated linoleic acid increased C-reactive protein in human subjects
复制标题
共轭亚油酸增加人类受试者的 C 反应蛋白
DOI：
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发表时间：
2005
影响因子：
3.6
通讯作者：
B. Vessby
中科院分区：
文献类型：
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作者：
A. Smedman;S. Basu;S. Jovinge;G. N. Fredrikson;B. Vessby
我们先前表明，共轭亚油酸（CLA）增加15-酮-二氢-前列腺素F2α，环氧合酶介导的脂质过氧化的标志物，因此环氧合酶介导的炎症的指标。本研究的目的是研究CLA对人类受试者其他炎症指标的影响，包括C-反应蛋白、TNF-α、TNF-α受体1和2以及血管细胞粘附分子-1。在一项双盲、安慰剂对照研究中，53名人类受试者补充了异构体顺式-9，反式-11 CLA和反式-10，顺式-12 CLA的混合物（4.2g/d）或对照油，持续3个月。与对照组相比，CLA补充增加了C-反应蛋白水平（P= 0.003）。然而，未检测到TNF-α、TNF-α受体1和2以及血管细胞粘附分子-1的变化。
We previously showed that conjugated linoleic acid (CLA) increases 15-keto-dihydro-prostaglandin F2α, a marker for cyclooxygenase-mediated lipid peroxidation and thus an indicator of cyclooxygenase-mediated inflammation. The aim of the present study was to investigate the effects of CLA on other indicators of inflammation in human subjects, including C-reactive protein, TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1. In a double-blind, placebo-controlled study, fifty-three human subjects were supplemented with a mixture (4·2g/d) of the isomers cis-9,trans-11 CLA and trans-10,cis-12 CLA or control oil for 3 months. CLA supplementation increased levels of C-reactive protein (P=0·003) compared with the control group. However, no changes in TNF-α, TNF-α receptors 1 and 2, and vascular cell adhesion molecule-1 were detected.
影响因子：
15.9
作者：
MARUI, N;OFFERMANN, MK;MEDFORD, RM
通讯作者：
MEDFORD, RM
影响因子：
3.2
作者：
Krieglstein, CF;Granger, DN
通讯作者：
Granger, DN
影响因子：
158.5
作者：
Ridker, PM;Cushman, M;Hennekens, CH
通讯作者：
Hennekens, CH