Development and Validation of an Integrated Computational Model of Cerebral Blood Flow and Oxygenation
Development and Validation of an Integrated Computational Model of Cerebral Blood Flow and Oxygenation
复制标题
脑血流和氧合综合计算模型的开发和验证
作者：
I. Moppett;J. Hardman
背景：不同的研究小组已经建立了脑血流和氧合的模拟和模型，每一个都有其优点和缺点。我们描述了一种新的计算模型，诺丁汉脑模拟器（NCS），设计用于实验和教学的发展和验证。方法：生理假设转化为微分方程，这些数值求解相对于时间。一组测试来自已发表的文献，以测试模拟：静态和动态自动调节反应;二氧化碳反应性;脑组织氧合。编制了网络控制系统的程序，对已发表的实验方法进行了模拟，并将模拟结果与已发表的数据进行了比较。结果：NCS结果在定性和定量上与已发表的数据相似。调节指数的数值为（括号内为已发表的数值）：自动调节指数0.9（0.9）;瞬时充血反应率1.3（1.3）;二氧化碳反应性2.4%-4.7% mmHg −1（2-4.5）;脑组织氧分压22 mmHg（20-100）。结论：NCS是一种可靠的脑血流和氧合模型，值得进一步作为实验和教学工具使用。
BACKGROUND:Various groups have constructed simulations and models of cerebral blood flow and oxygenation, each with its strengths and weaknesses. We describe the development and validation of a novel computational model, the Nottingham cerebral simulator (NCS), designed for experimental and teaching use. METHODS:Physiological hypotheses were converted into differential equations; these are solved numerically with respect to time. A battery of tests was derived from published literature against which to test the simulation: static and dynamic autoregulation responses; carbon dioxide reactivity; brain tissue oxygenation. The NCS was programmed to simulate the methodologies of published experiments and the results of the simulation and the published data were compared. RESULTS:The NCS results are qualitatively and quantitatively similar to published data. The values for regulatory indices were (published values in parentheses): index of autoregulation 0.9 (0.9); transient hyperemic response ratio 1.3 (1.3), carbon dioxide reactivity 2.4%–4.7% mm Hg−1 (2–4.5); brain tissue oxygen tension 22 mm Hg (20–100). CONCLUSIONS:The NCS is a credible model of cerebral blood flow and oxygenation, which warrants further use as an experimental and teaching tool.
影响因子：
8.3
作者：
TIECKS, FP;LAM, AM;NEWELL, DW
通讯作者：
NEWELL, DW