Sleep disturbances and frailty status in older community-dwelling men.
Sleep disturbances and frailty status in older community-dwelling men.
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DOI：
10.1111/j.1532-5415.2009.02490.x
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发表时间：
2009-11
影响因子：
6.3
通讯作者：
Osteoporotic Fractures in Men Study Group
中科院分区：
文献类型：
--
作者：
Ensrud KE;Blackwell TL;Redline S;Ancoli-Israel S;Paudel ML;Cawthon PM;Dam TT;Barrett-Connor E;Leung PC;Stone KL;Osteoporotic Fractures in Men Study Group
验证睡眠障碍与老年男性虚弱的证据独立相关的假设。前瞻性队列研究的横断面分析美国6家中心3133名≥67岁男性自我报告的睡眠参数（问卷）;睡眠觉醒模式的客观参数（平均收集5.2个晚上的体动记录数据）;以及睡眠呼吸障碍、夜间低氧血症和周期性腿部运动伴觉醒（PLMA）的客观参数（家庭过夜多导睡眠图）。使用与心血管健康研究虚弱指数中使用的标准相似的标准，将虚弱状态分类为健壮、中期或虚弱。睡眠障碍的发生率包括睡眠质量差、白天嗜睡过多、睡眠时间短、睡眠效率降低、睡眠潜伏期延长、睡眠碎片（更大的夜间觉醒和频繁的长时间觉醒事件），睡眠呼吸障碍，夜间低氧血症和频繁的PLMA在健壮男性中最低，在中间阶段组的男性中居中，在体弱男性中最高（所有睡眠参数的趋势p ≤0.002）。在调整多个潜在混杂因素后，自我报告睡眠质量差（匹兹堡睡眠质量指数<5，多变量比值比（莫尔）1.28，95%CI 1.09-1.50），睡眠效率<70%（莫尔比1.37，95% CI 1.12-1.67），睡眠潜伏期≥60分钟（莫尔比1.42，95%置信区间1.10-1.82），睡眠呼吸障碍（呼吸紊乱指数≥15，莫尔1.38，95% CI 1.15-1.65）均与更严重虚弱状态的几率增加独立相关。睡眠障碍包括自我报告的睡眠质量差、睡眠效率降低、睡眠潜伏期延长和睡眠呼吸障碍，这些都与更大的虚弱证据独立相关。
Test the hypothesis that sleep disturbances are independently associated with greater evidence of frailty in older men. Cross-sectional analysis of prospective cohort study Six U.S. centers 3133 men ≥67 years Self reported sleep parameters (questionnaire); objective parameters of sleep wake patterns (actigraphy data collected for an average of 5.2 nights); and objective parameters of sleep disordered breathing, nocturnal hypoxemia, and periodic leg movements with arousals (PLMA) (in-home overnight polysomnography). Frailty status classified as robust, intermediate stage or frail using criteria similar to those used in the Cardiovascular Health Study frailty index. The prevalence of sleep disturbances including poor sleep quality, excessive daytime sleepiness, short sleep duration, reduced sleep efficiency, prolonged sleep latency, sleep fragmentation (greater nighttime wakefulness and frequent long wake episodes), sleep disordered breathing, nocturnal hypoxemia and frequent PLMA was lowest among robust men, intermediate among men in the intermediate stage group, and highest among frail men (p-for-trend ≤0.002 for all sleep parameters). After adjusting for multiple potential confounders, self-reported poor sleep quality (Pittsburgh Sleep Quality Index <5, multivariable odds ratio (MOR) 1.28, 95%CI 1.09–1.50), sleep efficiency <70% (MOR 1.37, 95% CI 1.12–1.67), sleep latency ≥60 minutes (MOR 1.42, 95% CI 1.10–1.82), and sleep disordered breathing (respiratory disturbance index ≥15, MOR 1.38, 95% CI 1.15–1.65) were each independently associated with an increased odds of greater frailty status. Sleep disturbances including poor self-reported sleep quality, reduced sleep efficiency, prolonged sleep latency and sleep disordered breathing are independently associated with greater evidence of frailty.
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影响因子：
4.8
作者：
Canales, Muna T.;Taylor, Brent C.;Ishani, Areef;Mehra, Reena;Steffes, Michael;Stone, Katie L.;Redline, Susan;Ensrud, Kristine E.
通讯作者：
Ensrud, Kristine E.
DOI：
10.1111/j.1532-5415.2006.00880.x
发表时间：
2006-10-01
影响因子：
6.3
作者：
Ensrud, Kristine E.;Blackwell, Terri L.;Stone, Katie L.
通讯作者：
Stone, Katie L.
DOI：
10.1093/gerona/61.3.262
发表时间：
2006-03-01
影响因子：
5.1
作者：
Bandeen-Roche, K;Xue, QL;Fried, LP
通讯作者：
Fried, LP
影响因子：
5.6
作者：
Gehrman, P;Stepnowsky, C;Ancoli-Israel, S
通讯作者：
Ancoli-Israel, S
影响因子：
5.6
作者：
ANCOLIISRAEL, S;KRIPKE, DF;KAPLAN, O
通讯作者：
KAPLAN, O