Mouse Models of Alzheimer's Disease.
Mouse Models of Alzheimer's Disease.
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DOI：
10.3389/fnmol.2022.912995
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发表时间：
2022
影响因子：
4.8
通讯作者：
Tomita, Taisuke
中科院分区：
文献类型：
--
作者：
Yokoyama, Miyabishara;Kobayashi, Honoka;Tatsumi, Lisa;Tomita, Taisuke
阿尔茨海默病（AD）是一种神经退行性疾病，其特征在于记忆丧失和人格改变，最终导致痴呆。AD的病理特征是老年斑和神经元缠结，其包括异常聚集的β-淀粉样肽（Aβ）和过度磷酸化的tau蛋白。为了开发AD的预防、诊断和治疗策略，必须建立能够再现AD病理生理过程的动物模型。本文综述了基于Aβ和tau蛋白的转基因、基因敲入和注射等AD小鼠模型的优缺点。我们还将讨论其他基于神经炎症的小鼠模型，因为最近的遗传学研究表明，小胶质细胞在AD的发病机制中至关重要。虽然每种小鼠模型都有其优点和缺点，但对AD病理生物学的进一步研究将导致建立更准确的小鼠模型，并加速创新疗法的发展。
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory loss and personality changes, eventually leading to dementia. The pathological hallmarks of AD are senile plaques and neurofibrillary tangles, which comprise abnormally aggregated β-amyloid peptide (Aβ) and hyperphosphorylated tau protein. To develop preventive, diagnostic, and therapeutic strategies for AD, it is essential to establish animal models that recapitulate the pathophysiological process of AD. In this review, we will summarize the advantages and limitations of various mouse models of AD, including transgenic, knock-in, and injection models based on Aβ and tau. We will also discuss other mouse models based on neuroinflammation because recent genetic studies have suggested that microglia are crucial in the pathogenesis of AD. Although each mouse model has its advantages and disadvantages, further research on AD pathobiology will lead to the establishment of more accurate mouse models, and accelerate the development of innovative therapeutics.
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DOI：
10.1084/jem.20200861
发表时间：
2020-11-02
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Barthélemy NR;Horie K;Sato C;Bateman RJ
通讯作者：
Bateman RJ
影响因子：
82.9
作者：
Citron, M;Westaway, D;Selkoe, DJ
通讯作者：
Selkoe, DJ
影响因子：
4
作者：
Bohrmann, Bernd;Baumann, Karlheinz;Loetscher, Hansruedi
通讯作者：
Loetscher, Hansruedi
DOI：
10.1056/nejmoa1706441
发表时间：
2018-05-03
期刊：
The New England journal of medicine
影响因子：
--
作者：
Egan MF;Kost J;Tariot PN;Aisen PS;Cummings JL;Vellas B;Sur C;Mukai Y;Voss T;Furtek C;Mahoney E;Harper Mozley L;Vandenberghe R;Mo Y;Michelson D
通讯作者：
Michelson D
影响因子：
17.1
作者：
Ayalon, Gai;Lee, Seung-Hye;Kerchner, Geoffrey A.
通讯作者：
Kerchner, Geoffrey A.