Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease.
Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer's disease.
复制标题
血浆磷酸化tau亚型追踪阿尔茨海默病的CNS变化
DOI：
10.1084/jem.20200861
复制
发表时间：
2020-11-02
期刊：
影响因子：
--
通讯作者：
Bateman RJ
中科院分区：
文献类型：
--
作者：
Barthélemy NR;Horie K;Sato C;Bateman RJ
Barthélemy等人使用质谱法表征血浆tau亚型，并评估其对阿尔茨海默病的诊断效用。他们证明，淀粉样蛋白增加了p-tau-217和p-tau-181的血浆tau磷酸化测量。他们的结果支持p-tau-217作为AD血浆生物标志物优于p-tau-181上级。阿尔茨海默病（AD）的高灵敏度和特异性血浆生物标志物有可能提高临床诊断准确性，并促进研究，包括预防和治疗试验的招募。我们最近报道了CSF tau蛋白过度磷酸化，尤其是T217，是无症状和有症状阶段β淀粉样变性的准确预测因子。在目前的研究中，我们通过质谱法确定血浆p-tau亚型检测AD病理学的潜在效用，并研究CSF和血浆tau亚型的谱关系。如先前在CSF中所述，血浆tau被截短。p-tau-217和p-tau-181的CSF和血浆测量值相关。在CSF和血浆之间未发现总tau水平和pS202测量的相关性。我们发现p-tau-217和p-tau-181对发现队列中的淀粉样斑块病理学具有高度特异性（n = 36，AUROC分别= 0.99和0.98）。在验证队列（n = 92）中，p-tau-217测量仍然特异于淀粉样蛋白状态（AUROC = 0.92），p-tau-181测量的特异性较低（AUROC = 0.75）。
Barthélemy et al. use mass spectrometry to characterize plasma tau isoforms and assess their diagnosis utility for Alzheimer’s disease. They demonstrate plasma tau phosphorylation measures of p-tau-217 and p-tau-181 are increased with amyloid. Their results support p-tau-217 is superior to p-tau-181 as an AD plasma biomarker. Highly sensitive and specific plasma biomarkers for Alzheimer’s disease (AD) have the potential to improve diagnostic accuracy in the clinic and facilitate research studies including enrollment in prevention and treatment trials. We recently reported CSF tau hyperphosphorylation, especially on T217, is an accurate predictor of β-amyloidosis at asymptomatic and symptomatic stages. In the current study, we determine by mass spectrometry the potential utility of plasma p-tau isoforms to detect AD pathology and investigate CSF and plasma tau isoforms’ profile relationships. Plasma tau was truncated as previously described in CSF. CSF and plasma measures of p-tau-217 and p-tau-181 were correlated. No correlation was found between CSF and plasma on total-tau levels and pS202 measures. We found p-tau-217 and p-tau-181 were highly specific for amyloid plaque pathology in the discovery cohort (n = 36, AUROC = 0.99 and 0.98 respectively). In the validation cohort (n = 92), p-tau-217 measures were still specific to amyloid status (AUROC = 0.92), and p-tau-181 measures were less specific (AUROC = 0.75).
登录
查看更多内容
影响因子：
9.9
作者：
Mattsson N;Zetterberg H;Janelidze S;Insel PS;Andreasson U;Stomrud E;Palmqvist S;Baker D;Tan Hehir CA;Jeromin A;Hanlon D;Song L;Shaw LM;Trojanowski JQ;Weiner MW;Hansson O;Blennow K;ADNI Investigators
通讯作者：
ADNI Investigators
影响因子：
12.7
作者：
Cicognola, Claudia;Brinkmalm, Gunnar;Hoglund, Kina
通讯作者：
Hoglund, Kina
影响因子：
3.8
作者：
Bulut, M;Koksal, O;Parlak, M
通讯作者：
Parlak, M
影响因子：
16.2
作者：
Bacioglu, Mehtap;Maia, Luis F.;Jucker, Mathias
通讯作者：
Jucker, Mathias
淀粉样蛋白β浓度和稳定的同位素标记人血浆特异性淀粉样变性的动力学。
DOI：
10.1016/j.jalz.2017.06.2266
发表时间：
2017-08
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
Ovod V;Ramsey KN;Mawuenyega KG;Bollinger JG;Hicks T;Schneider T;Sullivan M;Paumier K;Holtzman DM;Morris JC;Benzinger T;Fagan AM;Patterson BW;Bateman RJ
通讯作者：
Bateman RJ