Dyslipidemia and associated risk factors among HIV/AIDS patients on HAART in Asmara, Eritrea.
Dyslipidemia and associated risk factors among HIV/AIDS patients on HAART in Asmara, Eritrea.
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DOI：
10.1371/journal.pone.0270838
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发表时间：
2022
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
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作者：
尽管高效抗逆转录病毒治疗（HAART）的开始导致了HIV/AIDS相关死亡率的降低，但据报道该方案与脂质毒性相关。需要关于这种干扰的基线数据，以诱导全国范围的艾滋病毒/艾滋病干预方案。本研究的目的是确定厄立特里亚接受HAART治疗的HIV患者血脂异常的频率和风险。对厄立特里亚阿斯马拉两所国家转诊医院的艾滋病毒/艾滋病患者进行了一项横断面研究。采用结构式问卷收集人口学资料，并采集血液样本进行血脂谱分析。采用SPSS软件进行卡方检验、事后检验和Logistic回归分析。该研究包括382名参与者，其中256名（67%）为女性。中位年龄45岁（IQR：38-51），中位CD 4 + T细胞数434岁（IQR：294-583），中位HAART时间5年（IQR：3-5）。血脂异常的患病率为331例（86.6%）。低密度脂蛋白-C（LDL-C）升高213（55.8%）是主要异常。阿巴卡韦与甘油三酯（TG）最高均值（228.17 ± 193.81）和高密度脂蛋白（HDL-C）最低均值（46.94 ± 12.02）显著相关。女性TG（aOR = 2.89，95% CI：1.65-5.05）和TC/HDL比值（aOR = 2.33，95% CI：1.40-3.87）的比例显著较高，HDL-C（aOR = 2.16，95% CI：1.34-3.48）较低。年龄增加与促动脉粥样硬化脂质参数增加有关。高LDL-C在非吸烟者中更少见（aOR = 0. 028，95% CI：0. 12 - 0. 69）。该研究显示，在厄立特里亚接受HAART的艾滋病毒患者中血脂异常的患病率很高。性别、年龄和吸烟习惯是与血脂异常相关的关键因素。在开始HAART治疗前必须评估血脂和其他心血管危险因素，并在治疗期间进行持续监测。
Though the initiation of Highly Active Antiretroviral Therapy (HAART) has led to decreased HIV/AIDS related mortality, the regimen has been reported to be associated with lipid toxicities. Baseline data on such disturbances are required to induce countrywide interventional HIV/AIDS programs. The aim of this study was to determine the frequency and risks of dyslipidemia in HIV patients on HAART medication in Eritrea. A cross sectional study was conducted on HIV/AIDS patients in two national referral hospitals in Asmara, Eritrea. A structured questionnaire was used to collect demographic data and blood sample was taken for analyses of lipid profile tests. Data was analyzed using chi-square test, Post Hoc and logistic regression in SPSS software. The study included 382 participants of whom 256(67%) were females. Their median age, CD4+ T cell count (cell/microliter) and duration of HAART (years) was 45(IQR: 38–51), 434(IQR: 294–583) & 5(IQR: 3–5) respectively. The prevalence of dyslipidemia was 331(86.6%). Increased Low Density Lipoprotein-C (LDL-C) 213(55.8%) was the predominant abnormality. Abacavir was significantly related with highest means of triglycerides (TG) (228.17 ± 193.81) and lowest means of High Density Lipoprotein (HDL-C) (46.94 ± 12.02). Females had substantially higher proportions of TG (aOR = 2.89, 95% CI: 1.65–5.05) and TC/HDL ratio (aOR = 2.33, 95% CI: 1.40–3.87) and low HDL-C (aOR = 2.16, 95% CI: 1.34–3.48). Increased age was related with increased pro-atherogenic lipid parameters. High LDL-C was more infrequent in non-smokers (aOR = 0.028, 95% CI: 0.12–0.69). The study showed a high prevalence of dyslipidemia in HIV-patients receiving HAART in Eritrea. Sex, age and smoking practice were among key factors associated with dyslipidemia. The necessity to assess lipid profiles and other cardiovascular risk factors before initiation of HAART treatment and continuous monitoring during therapy is mandatory.
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在程序中切换到二线艺术的因果效应，而无需访问常规病毒载荷监测。
DOI：
10.1097/qad.0b013e32834e1b5f
发表时间：
2012-01-02
期刊：
AIDS (London, England)
影响因子：
--
作者：
Gsponer T;Petersen M;Egger M;Phiri S;Maathuis MH;Boulle A;Musondad P;Tweya H;Peter K;Chi BH;Keiser O;IeDEA Southern Africa
通讯作者：
IeDEA Southern Africa
影响因子：
--
作者：
Brown, TT;Cole, SR;Dobs, AS
通讯作者：
Dobs, AS
影响因子：
3.8
作者：
Mary-Krause, M;Cotteb, L;Costagliola, D
通讯作者：
Costagliola, D
影响因子：
3.8
作者：
Carr, A;Samaras, K;Cooper, DA
通讯作者：
Cooper, DA
影响因子：
120.7
作者：
Carroll, MD;Lacher, DA;Johnson, CL
通讯作者：
Johnson, CL