Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult population-based study.
Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult population-based study.
复制标题
DOI：
10.3109/00365521.2013.792389
复制
发表时间：
2013-07
影响因子：
1.9
通讯作者：
Ronkainen J
中科院分区：
文献类型：
--
作者：
Ludvigsson JF;Aro P;Walker MM;Vieth M;Agréus L;Talley NJ;Murray JA;Ronkainen J
Coeliac disease (CD) has been linked to gastro-oesophageal reflux disease (GORD) and eosinophilic oesophagitis (EoE), but population-based studies of the prevalence of CD in these conditions are lacking, that is, the aim of this study. An endoscopic study of 1000 randomly selected adults from the general population. CD was defined on the basis of positive serology in parallel with mucosal abnormalities of the small intestine. Any eosinophil infiltration of the oesophageal epithelium was defined as oesophageal eosinophilia and EoE was defined as having at least 15 eosinophils/high power field in biopsies from the distal oesophagus. We used Fisher’s exact test to compare the prevalence of GORD, oesophageal eosinophilia and EoE in subjects with CD vs. controls. 400 subjects (40%) had gastro-oesophageal reflux symptoms (GORS), 155 (15.5%) had erosive oesophagitis, 16 (1.6%) had Barrett’s oesophagus, 48 (4.8%) had oesophageal eosinophilia and 11 (1.1%) had EoE. CD was diagnosed in 8/400 (2.0%) individuals with GORS (vs. controls: 10/600 (1.7%), p=0.81), in 3/155 (1.9%) with erosive oesophagitis (vs. 15/845 controls (1.8%), p=0.75) and in 2/48 (4.2%) individuals with oesophageal eosinophilia (controls: 16/952 (1.7%) p=0.21), but in none of those 16 with Barrett’s oesophagus (vs. 18/984 controls (1.8%), p=1.0) or of the 11 individuals with EoE (controls: 18/989 (1.8%), p=1.0). This population-based study found no increased risk of CD among individuals with GORD, oesophageal eosinophilia or EoE. CD screening of individuals with GORD or EoE of individuals with CD cannot be recommended.
登录
查看更多内容
影响因子：
7.6
作者：
Quaglietta, L.;Coccorullo, P.;Staiano, A.
通讯作者：
Staiano, A.
影响因子：
12.6
作者：
Nachman, Fabio;Vazquez, Horacio;Cesar Bai, Julio
通讯作者：
Cesar Bai, Julio
影响因子：
24.5
作者：
Lundell, LR;Dent, J;Wallin, L
通讯作者：
Wallin, L
DOI：
10.1097/00005176-199302000-00013
发表时间：
1993-02-01
影响因子：
2.9
作者：
ODERDA, G;FORNI, M;ANSALDI, N
通讯作者：
ANSALDI, N
影响因子：
1.9
作者：
Aro, P;Ronkainen, J;Agréus, L
通讯作者：
Agréus, L