Amino acid metabolism in primary bone sarcomas.
Amino acid metabolism in primary bone sarcomas.
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DOI：
10.3389/fonc.2022.1001318
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发表时间：
2022
影响因子：
4.7
通讯作者：
Lyssiotis, Costas A.
中科院分区：
文献类型：
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作者：
Jimenez, Jennifer A.;Lawlor, Elizabeth R.;Lyssiotis, Costas A.
原发性骨肉瘤，包括骨肉瘤（OS）和尤文肉瘤（ES），是侵袭性肿瘤，在儿童和青少年中发病率最高。这些患者的强化标准治疗包括联合手术和/或放疗以及最大剂量的化疗;这种方案几十年来没有改善。与其他肿瘤类型一样，ES和OS的特征在于失调的细胞代谢和代谢途径的重新布线以支持恶性生长的生物合成需求。不仅癌细胞具有瓦尔堡代谢或有氧糖酵解的特征，而且新兴的工作揭示了对氨基酸代谢的依赖性。除了并入蛋白质，氨基酸在氧化还原平衡、能量稳态和表观遗传维持中起关键作用。在这篇综述中，我们总结了目前的研究描述的氨基酸代谢要求的原发性骨肉瘤，专注于OS和ES，并比较这些依赖性在正常骨和恶性肿瘤的情况下。我们还研究了可以从其他癌症中收集的见解，以更好地了解原发性和转移性肿瘤微环境之间的差异代谢能力。最后，我们讨论了潜在的代谢脆弱性，可以利用治疗，并提供更有针对性的治疗，以提高目前的护理标准。
Primary bone sarcomas, including osteosarcoma (OS) and Ewing sarcoma (ES), are aggressive tumors with peak incidence in childhood and adolescence. The intense standard treatment for these patients consists of combined surgery and/or radiation and maximal doses of chemotherapy; a regimen that has not seen improvement in decades. Like other tumor types, ES and OS are characterized by dysregulated cellular metabolism and a rewiring of metabolic pathways to support the biosynthetic demands of malignant growth. Not only are cancer cells characterized by Warburg metabolism, or aerobic glycolysis, but emerging work has revealed a dependence on amino acid metabolism. Aside from incorporation into proteins, amino acids serve critical functions in redox balance, energy homeostasis, and epigenetic maintenance. In this review, we summarize current studies describing the amino acid metabolic requirements of primary bone sarcomas, focusing on OS and ES, and compare these dependencies in the normal bone and malignant tumor contexts. We also examine insights that can be gleaned from other cancers to better understand differential metabolic susceptibilities between primary and metastatic tumor microenvironments. Lastly, we discuss potential metabolic vulnerabilities that may be exploited therapeutically and provide better-targeted treatments to improve the current standard of care.
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影响因子：
5.2
作者：
Chiu M;Toscani D;Marchica V;Taurino G;Costa F;Bianchi MG;Andreoli R;Franceschi V;Storti P;Burroughs-Garcia J;Eufemiese RA;Dalla Palma B;Campanini N;Martella E;Mancini C;Shan J;Kilberg MS;D'Amico G;Dander E;Agnelli L;Pruneri G;Donofrio G;Bussolati O;Giuliani N
通讯作者：
Giuliani N
癌症相关的间充质基质通过NF-κB激活对肿瘤内酸中毒的响应，促成骨肉瘤细胞的干性。
影响因子：
6.4
作者：
Avnet S;Di Pompo G;Chano T;Errani C;Ibrahim-Hashim A;Gillies RJ;Donati DM;Baldini N
通讯作者：
Baldini N
影响因子：
5.9
作者：
Anso E;Mullen AR;Felsher DW;Matés JM;Deberardinis RJ;Chandel NS
通讯作者：
Chandel NS
影响因子：
8.8
作者：
Chen X;Bahrami A;Pappo A;Easton J;Dalton J;Hedlund E;Ellison D;Shurtleff S;Wu G;Wei L;Parker M;Rusch M;Nagahawatte P;Wu J;Mao S;Boggs K;Mulder H;Yergeau D;Lu C;Ding L;Edmonson M;Qu C;Wang J;Li Y;Navid F;Daw NC;Mardis ER;Wilson RK;Downing JR;Zhang J;Dyer MA;St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project
通讯作者：
St. Jude Children’s Research Hospital–Washington University Pediatric Cancer Genome Project
影响因子：
9
作者：
通讯作者：
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