Advancing age increases the size and severity of spontaneous atheromas in mouse models of atherosclerosis.
Advancing age increases the size and severity of spontaneous atheromas in mouse models of atherosclerosis.
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DOI：
10.1007/s11357-023-00776-8
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发表时间：
2023-06
期刊：
影响因子：
5.6
通讯作者：
Lesniewski, Lisa A.
中科院分区：
文献类型：
--
作者：
Gogulamudi, Venkateswara R.;Durrant, Jessica R.;Adeyemo, Adelola O.;Ho, Huynh Mi;Walker, Ashley E.;Lesniewski, Lisa A.
使用多种小鼠模型，我们探讨了衰老对动脉粥样硬化病变的大小和严重程度的影响。在年轻、中年和老年载脂蛋白E基因敲除小鼠（ApoE−/−）中，喂食致动脉粥样硬化饮食（AD）3-8周，评估降主动脉和主动脉根部斑块/粥样硬化形成以及颈动脉部分结扎（PCL）后颈动脉粥样硬化发展。总胆固醇、低密度脂蛋白胆固醇和甘油三酯在老年人中高于其他两个年龄组，无论AD持续时间如何。所有年龄段的主动脉斑块负荷均随AD持续时间的增加而增加。主动脉根部粥样硬化的大小和斑块形态等级随年龄增加而升高;然而，年龄对PCL后颈动脉粥样硬化的大小或严重程度没有影响。另外，我们通过腺相关病毒介导的LDL受体调节因子Pcsk 9的上调和5周的AD在年轻和年老的C57 BL/6小鼠中诱导高脂血症。尽管与年轻的Pcsk 9小鼠相比，老年小鼠的胆固醇较低，但老年小鼠的主动脉根部粥样硬化的大小和严重程度更大。然而，与ApoE−/−小鼠一样，Pcsk 9小鼠中年龄对PCL诱导的颈动脉粥样硬化的大小或严重程度没有影响。总之，这些结果表明，老化增加自发性主动脉粥样硬化的大小和严重程度。在线版本包含补充材料，可通过10.1007/s11357-023-00776-8获得。
Using multiple mouse models, we explored the impact of aging on the size and severity of atherosclerotic lesions. In young, middle-aged and old apolipoprotein E knockout mice (ApoE−/−) fed an atherogenic diet (AD) for 3–8 weeks, plaque/atheroma formation in the descending aorta and aortic root, and atheroma development in the carotid in response to partial carotid ligation (PCL) were assessed. Total and LDL cholesterol, and triglycerides were higher in old compared to both other age groups, regardless of AD duration. Aortic plaque burden increased with AD duration in all ages. The size and plaque morphology grade of aortic root atheromas was higher with age; however, there was no effect of age on the size or severity of carotid atheromas after PCL. We additionally induced hyperlipidemia in young and old C57BL/6 mice by adeno-associated virus mediated upregulation of LDL receptor regulator, Pcsk9, and 5 weeks of AD. Despite lower cholesterol in old compared to young Pcsk9 mice, there was a greater size and severity of aortic root atheromas in old mice. However, like the ApoE−/− mice, there was no effect of age on size or severity of PCL-induced carotid artery atheromas in Pcsk9 mice. Together, these results suggest that aging increases the size and severity of spontaneous aortic atheromas. The online version contains supplementary material available at 10.1007/s11357-023-00776-8.
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影响因子：
37.8
作者：
Go AS;Mozaffarian D;Roger VL;Benjamin EJ;Berry JD;Blaha MJ;Dai S;Ford ES;Fox CS;Franco S;Fullerton HJ;Gillespie C;Hailpern SM;Heit JA;Howard VJ;Huffman MD;Judd SE;Kissela BM;Kittner SJ;Lackland DT;Lichtman JH;Lisabeth LD;Mackey RH;Magid DJ;Marcus GM;Marelli A;Matchar DB;McGuire DK;Mohler ER 3rd;Moy CS;Mussolino ME;Neumar RW;Nichol G;Pandey DK;Paynter NP;Reeves MJ;Sorlie PD;Stein J;Towfighi A;Turan TN;Virani SS;Wong ND;Woo D;Turner MB;American Heart Association Statistics Committee and Stroke Statistics Subcommittee
通讯作者：
American Heart Association Statistics Committee and Stroke Statistics Subcommittee
影响因子：
8.3
作者：
Meschia JF;Bushnell C;Boden-Albala B;Braun LT;Bravata DM;Chaturvedi S;Creager MA;Eckel RH;Elkind MS;Fornage M;Goldstein LB;Greenberg SM;Horvath SE;Iadecola C;Jauch EC;Moore WS;Wilson JA;American Heart Association Stroke Council;Council on Cardiovascular and Stroke Nursing;Council on Clinical Cardiology;Council on Functional Genomics and Translational Biology;Council on Hypertension
通讯作者：
Council on Hypertension
膳食补充雷帕霉素可逆转与年龄相关的血管功能障碍和氧化应激，同时调节营养感应、细胞周期和衰老途径。
影响因子：
7.8
作者：
Lesniewski LA;Seals DR;Walker AE;Henson GD;Blimline MW;Trott DW;Bosshardt GC;LaRocca TJ;Lawson BR;Zigler MC;Donato AJ
通讯作者：
Donato AJ
DOI：
10.1161/hypertensionaha.110.165365
发表时间：
2011-03
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Padilla J;Simmons GH;Fadel PJ;Laughlin MH;Joyner MJ;Casey DP
通讯作者：
Casey DP
影响因子：
3.9
作者：
Lesniewski, Lisa A.;Zigler, Melanie L.;Durrant, Jessica R.;Nowlan, Molly J.;Folian, Brian J.;Donato, Anthony J.;Seal, Douglas R.
通讯作者：
Seal, Douglas R.