Representing information in cell assemblies: persistent activity mediated by semilunar granule cells.
Representing information in cell assemblies: persistent activity mediated by semilunar granule cells.
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DOI：
10.1038/nn.2458
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发表时间：
2010-02
影响因子：
25
通讯作者：
Strowbridge BW
中科院分区：
文献类型：
--
作者：
Larimer P;Strowbridge BW
Using rat hippocampal slices, we found that perforant path stimulation evokes long-lasting barrages of synaptic inputs in subpopulations of dentate gyrus mossy cells and hilar interneurons. Synaptic barrages could trigger persistent firing in hilar neurons. We found that synaptic barrages originate from semilunar granule cells (SGCs), glutamatergic neurons in the inner molecular layer that generate long-duration plateau potentials in response to excitatory synaptic input. MK801, nimodipine, and nickel all abolished stimulus-evoked plateau potentials in SGCs, and synaptic barrages in downstream hilar neurons, without blocking fast synaptic transmission. Hilar up-states triggered functional inhibition in granule cells that persisted for >10 s. Hilar cell assemblies, assayed by simultaneous triple and paired intracellular recordings, were linked by persistent firing in SGCs. Population responses recorded in hilar neurons accurately encoded stimulus identity. Stimulus-evoked up-states in dentate gyrus represent a potential cellular basis for hippocampal working memory.
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影响因子：
2.5
作者：
Lo, FS;Erzurumlu, RS
通讯作者：
Erzurumlu, RS
影响因子：
1.9
作者：
COLOMBO, M;GROSS, CG
通讯作者：
GROSS, CG
影响因子：
2.5
作者：
MCCORMICK, DA;CONNORS, BW;PRINCE, DA
通讯作者：
PRINCE, DA
DOI：
10.1523/jneurosci.3612-08.2008
发表时间：
2008-11-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Larimer P;Strowbridge BW
通讯作者：
Strowbridge BW
影响因子：
5.3
作者：
Koschak, Alexandra;Obermair, Gerald J.;Pietrobon, Daniela
通讯作者：
Pietrobon, Daniela