The effect of acute exercise on collagen turnover in human tendons: influence of prior immobilization period
The effect of acute exercise on collagen turnover in human tendons: influence of prior immobilization period
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急性运动对人体肌腱胶原蛋白更新的影响：之前固定时间的影响
DOI：
--
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发表时间：
2013
影响因子：
3
通讯作者：
H. Langberg
中科院分区：
文献类型：
--
作者：
L. Moerch;J. Pingel;M. Boesen;M. Kjaer;H. Langberg
人体肌腱机械负荷可刺激胶原合成，但急性负荷反应与肌腱训练状态之间的关系尚不清楚。我们测试了长期负荷剥夺对急性负荷诱导的人跟腱胶原代谢的影响，方法是在同一个体内对相对未经训练的跟腱(急性负荷前2周的固定期)和习惯性负荷的对侧跟腱分别施加相同的绝对负荷。8名未经训练的健康男性的一条腿完全静止了2周，而对侧的腿则习惯于使用。手术后，在1小时的跑步机跑步中，跟腱和小腿肌肉都承受着相同的绝对负荷。通过微透析法测量两个跟腱周围固定后运动前的组织胶原转换率，并与运动后72小时的数值进行比较。能量多普勒监测跟腱内血流速度的变化，MRI定量测定肌腱横截面积的变化。急性负荷导致两个跟腱在跑步后72小时胶原合成增加(P<0.05)，但无显著差异。能量多普勒未显示急性肌腱超负荷的迹象，肌腱横截面积也未因制动和重新加载而改变。目前的研究表明，2周的肌腱负荷剥夺不足以影响正常的对负荷的适应性反应，负荷被确定为人类跟腱周围组织胶原合成增加。
Mechanical loading of human tendon stimulates collagen synthesis, but the relationship between acute loading responses and training status of the tendon is not clear. We tested the effect of prolonged load deprivation on the acute loading-induced collagen turnover in human tendons, by applying the same absolute load to a relative untrained Achilles tendon (2-week immobilization period prior to acute loading) and a habitually loaded contra-lateral Achilles tendon, respectively, within the same individuals. Eight untrained, healthy males had one lower limb totally immobilized for 2 weeks, whereas the contra-lateral leg was used habitually. Following the procedure both Achilles tendons and calf muscles were loaded with the same absolute load during a 1-h treadmill run. Tissue collagen turnover was measured by microdialysis performed post-immobilization but pre-exercise around both Achilles tendons and compared to values obtained by 72-h post-exercise. Power Doppler was used to monitor alterations in intratendinous blood flow velocity of the Achilles tendon and MRI used to quantitate changes in tendon cross-section area. Acute loading resulted in an increased collagen synthesis 72 h after the run in both Achilles tendons (p < 0.05) with no significant difference. No signs of acute tendon overloading were demonstrated by Power Doppler, and tendon cross-section area did not change as a result of immobilization and reloading. The present study indicates that 2 weeks of tendon load deprivation is not sufficient to affect the normal adaptive response to loading determined as increased collagen synthesis of peritendinous Achilles tendon tissue in humans.
运动对猪指屈肌腱生物力学和生化特性的影响。
DOI：
10.1115/1.3138246
发表时间：
1981
期刊：
Journal of biomechanical engineering
影响因子：
--
作者：
Woo,SL;Gomez,MA;Amiel,D;Ritter,MA;Gelberman,RH;Akeson,WH
通讯作者：
Akeson,WH
慢性卸载和康复对人类跟腱特性的影响：速度编码相位对比 MRI 研究。
DOI：
10.1152/japplphysiol.90699.2008
发表时间：
2008
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
--
作者：
Shin,Dongsuk;Finni,Taija;Ahn,Sinyeob;Hodgson,JohnA;Lee,Hae-Dong;Edgerton,VReggie;Sinha,Shantanu
通讯作者：
Sinha,Shantanu
影响因子：
3.3
作者：
Sun, Yu-Long;Thoreson, Andrew R.;Amadio, Peter C.
通讯作者：
Amadio, Peter C.