Co-occurrence of congenital anomalies by maternal race/ethnicity among infants and fetuses with Down syndrome, 2013-2017: A U.S. population-based analysis.
Co-occurrence of congenital anomalies by maternal race/ethnicity among infants and fetuses with Down syndrome, 2013-2017: A U.S. population-based analysis.
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DOI：
10.1002/bdr2.1975
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发表时间：
2022-01-15
影响因子：
2.1
通讯作者：
National Birth Defects Prevention Network
中科院分区：
文献类型：
--
作者：
Stallings EB;Isenburg JL;Heinke D;Sherman SL;Kirby RS;Lupo PJ;National Birth Defects Prevention Network
与一般人群相比，唐氏综合征（DS）患者的其他先天性异常，特别是心血管缺陷的患病率更高。一些报告表明，在美国，活产婴儿中DS的患病率因种族和民族而异。我们的目的是检查2013-2017年期间出生的诊断为DS的婴儿和胎儿中，按母亲种族/种族划分的共发先天性异常的变化。国家出生缺陷监测系统（N = 12）提交了2013-2017年期间出生的诊断为DS的婴儿和胎儿的数据。我们计算了合并发生的主要和次要先天性异常的患病率，按器官系统，和四个选定的心血管出生缺陷，所有分层的母亲种族/民族。在5，836例DS病例中，79.7%有一个或多个共同发生的先天性异常。西班牙裔母亲所生的婴儿和胎儿中合并先天性异常的比例较高。最低比例的并发先天性异常，包括三个四个单独的心血管疾病检查，是在婴儿/胎儿出生的非西班牙裔美国印第安人/阿拉斯加原住民母亲。我们描述了在母体种族/民族群体中DS与其他先天性异常共现的差异。这些数据可能有助于将未来的研究重点放在种族/族裔群体之间在诊断和报告诊断为DS的婴儿/胎儿中合并发生的先天性异常方面的差异上。
Individuals with Down syndrome (DS) have a higher prevalence of additional congenital anomalies, especially cardiovascular defects, compared to the general population. Several reports have indicated that the prevalence of DS among live births varies by race and ethnicity within the United States. We aim to examine variations in co-occurring congenital anomalies by maternal race/ethnicity among infants and fetuses diagnosed with DS born during 2013–2017. State birth defect surveillance systems (N = 12) submitted data on infants and fetuses diagnosed with DS born during 2013–2017. We calculated the prevalence of co-occurring major and minor congenital anomalies, by organ system, and four selected cardiovascular birth defects, all stratified by maternal race/ethnicity. Among 5,836 cases of DS, 79.7% had one or more co-occurring congenital anomalies. There was a higher percentage of co-occurring congenital anomalies among infants and fetuses born to Hispanic mothers. The lowest percentage of co-occurring congenital anomalies, including three out of the four individual cardiovascular conditions examined, was among infants/fetuses born to non-Hispanic American Indian/Alaska Native mothers. We describe differences in DS co-occurrence with additional congenital anomalies among maternal racial/ethnic groups. These data may help focus future research on differences among racial/ethnic groups in the diagnosis and reporting of co-occurring congenital anomalies in infants/fetuses diagnosed with DS.
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影响因子：
2.1
作者：
Heinke D;Isenburg JL;Stallings EB;Short TD;Le M;Fisher S;Shan X;Kirby RS;Nguyen HH;Nestoridi E;Nembhard WN;Romitti PA;Salemi JL;Lupo PJ;National Birth Defects Prevention Network
通讯作者：
National Birth Defects Prevention Network
影响因子：
2
作者：
de Graaf, Gert;Buckley, Frank;Skotko, Brian G.
通讯作者：
Skotko, Brian G.
影响因子：
8.8
作者：
Conroy S;Murray EJ
通讯作者：
Murray EJ
影响因子：
8.8
作者：
Freeman, Sallie B.;Bean, Lora H.;Sherman, Stephanie L.
通讯作者：
Sherman, Stephanie L.
影响因子：
12.7
作者：
Canfield, Mark A.;Mai, Cara T.;Kirby, Russell S.
通讯作者：
Kirby, Russell S.