Association of circulating branched-chain amino acids with cardiometabolic traits differs between adults and the oldest-old.
Association of circulating branched-chain amino acids with cardiometabolic traits differs between adults and the oldest-old.
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成人和老年人之间循环支链氨基酸与心脏代谢特征的关联存在差异
DOI：
10.18632/oncotarget.21489
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发表时间：
2017-10-24
期刊：
影响因子：
--
通讯作者：
Yang Z
中科院分区：
文献类型：
--
作者：
Sun L;Hu C;Yang R;Lv Y;Yuan H;Liang Q;He B;Pang G;Jiang M;Dong J;Yang Z
支链氨基酸（BCAA）因其潜在的抗衰老作用而前景广阔。然而，成人研究结果表明循环支链氨基酸与心脏代谢风险相关。此外，关于 BCAA 如何影响老年人（> 85 岁）的集群心脏代谢特征的信息很少，而老年人是发达国家人口增长最快的部分。在这里，我们基于长寿队列，应用靶向代谢组学方法来测量中国参与者（21-110 岁）的血清支链氨基酸。比较了支链氨基酸三分位数的定量和二分心脏代谢特征的差异。使用广义相加模型 (GAM) 探讨支链氨基酸与代谢综合征 (MetS) 风险之间的剂量反应关系。总体而言，支链氨基酸与大多数检查的心脏代谢特征相关。调整年龄和性别后，增加 BCAA 三分位数的 MetS 比值比为 3.22 (1.70 – 6.12) 和 5.27 (2.88 – 9.94，参考三分位数 1) (Ptrend < 0.001)。在进一步控制生活方式因素和炎症因素后，这种关联仍然存在。然而，除了血脂外，循环支链氨基酸与数量性状之间的相关性在最年长的老年人中减弱，血脂水平与成人明显不同。分层分析还表明，危险的 BCAAs-MetS 关联在成年人中比在老年人中更明显。此外，基于广义加性模型 (GAM) 的曲线拟合表明，只有当 BCAA 超过阈值（约 450 μmol/L）时，BCAA-MetS 关联才显着。这种关系可能与年龄有关，并且在成年人中比在老年人中更为明显。
Branched-chain amino acids (BCAAs) are promising for their potential anti-aging effects. However, findings in adults suggest that circulating BCAAs are associated with cardiometabolic risk. Moreover, little information is available about how BCAAs influence clustered cardiometabolic traits in the oldest-old (>85 years), which are the fastest-growing segment of the population in developed countries. Here, we applied a targeted metabolomics approach to measure serum BCAAs in Chinese participants (aged 21-110 years) based on a longevity cohort. The differences of quantitative and dichotomous cardiometabolic traits were compared across BCAAs tertiles. A generalized additive model (GAM) was used to explore the dose-response relationship between BCAAs and the risk of metabolic syndrome (MetS). Overall, BCAAs were correlated with most of the examined cardiometabolic traits. The odds ratios for MetS across the increasing BCAA tertiles were 3.22 (1.70 – 6.12) and 5.27 (2.88 – 9.94, referenced to tertile 1) after adjusting for age and gender (Ptrend < 0.001). The association still existed after further controlling for lifestyle factors and inflammation factors. However, the correlations between circulating BCAAs and quantitative traits were weakened in the oldest-old, except for lipids, the levels of which were distinctly different from those in adults. The stratified analysis also suggested that the risky BCAAs-MetS association was more pronounced in adults than in the oldest-old. Moreover, generalized additive model (GAM)-based curve-fitting suggested that only when BCAAs exceeded a threshold (approximately 450 μmol/L) was the BCAAs-MetS association significant. The relationship might be aging-dependent and was more pronounced in adults than in the oldest-old.
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影响因子：
3.5
作者：
Corsetti, Giovanni;D'Antona, Giuseppe;Ruocco, Chiara;Stacchiotti, Alessandra;Romano, Claudia;Tedesco, Laura;Dioguardi, Francesco;Rezzani, Rita;Nisoli, Enzo
通讯作者：
Nisoli, Enzo
影响因子：
7.8
作者：
Alvers AL;Fishwick LK;Wood MS;Hu D;Chung HS;Dunn WA Jr;Aris JP
通讯作者：
Aris JP
DOI：
10.1161/hcg.0000000000000032
发表时间：
2017-04
期刊：
Circulation. Cardiovascular genetics
影响因子：
--
作者：
Cheng S;Shah SH;Corwin EJ;Fiehn O;Fitzgerald RL;Gerszten RE;Illig T;Rhee EP;Srinivas PR;Wang TJ;Jain M;American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council
通讯作者：
American Heart Association Council on Functional Genomics and Translational Biology; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Stroke Council
影响因子：
16.2
作者：
Ford, ES
通讯作者：
Ford, ES
影响因子：
5.9
作者：
Goffredo M;Santoro N;Tricò D;Giannini C;D'Adamo E;Zhao H;Peng G;Yu X;Lam TT;Pierpont B;Caprio S;Herzog RI
通讯作者：
Herzog RI