Quantitative neuropathological assessment to investigate cerebral multi-morbidity.
Quantitative neuropathological assessment to investigate cerebral multi-morbidity.
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DOI：
10.1186/s13195-014-0085-y
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Nelson PT
中科院分区：
文献类型：
--
作者：
Attems J;Neltner JH;Nelson PT
脑老化的特征是多种病理同时存在，并且脑多发病率随年龄增加而增加。为了了解病理学各亚型的影响以及脑多发病对临床体征和症状的综合影响，进行了大量的临床病理相关研究。然而，这样的研究往往是基于半定量评估的神经病理学标志性病变。在这里，我们讨论了一些高通量定量神经病理学评估的新方法。这些方法联合收割机将增加的定量精确性与计算机和网络分析的附加技术能力结合起来。有大量的新的机会-与特定的技术，包括载玻片扫描仪，自动显微镜和组织微阵列-也有潜在的陷阱。我们的结论是，定量和数字化的神经病理学方法将是关键资源，以进一步阐明大脑的多发病率在老年人的大脑，也有可能改变常规的神经病理学诊断。
The aging brain is characterized by the simultaneous presence of multiple pathologies, and the prevalence of cerebral multi-morbidity increases with age. To understand the impact of each subtype of pathology and the combined effects of cerebral multi-morbidity on clinical signs and symptoms, large clinico-pathological correlative studies have been performed. However, such studies are often based on semi-quantitative assessment of neuropathological hallmark lesions. Here, we discuss some of the new methods for high-throughput quantitative neuropathological assessment. These methods combine increased quantitative rigor with the added technical capacity of computers and networked analyses. There are abundant new opportunities - with specific techniques that include slide scanners, automated microscopes, and tissue microarrays - and also potential pitfalls. We conclude that quantitative and digital neuropathologic approaches will be key resources to further elucidate cerebral multi-morbidity in the aged brain and also hold the potential for changing routine neuropathologic diagnoses.
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影响因子：
12.7
作者：
Janocko NJ;Brodersen KA;Soto-Ortolaza AI;Ross OA;Liesinger AM;Duara R;Graff-Radford NR;Dickson DW;Murray ME
通讯作者：
Murray ME
影响因子：
2.4
作者：
Kovacs, Gabor G.;Alafuzoff, Irina;Budka, Herbert
通讯作者：
Budka, Herbert
影响因子：
1.1
作者：
Jellinger, Kurt A.;Attems, Johannes
通讯作者：
Attems, Johannes
DOI：
10.1097/00005072-199702000-00007
发表时间：
1997-02-01
影响因子：
3.2
作者：
Nagy, Z;Esiri, MM;Smith, AD
通讯作者：
Smith, AD
衰老导致的海马硬化是一种普遍且高发病率的脑部疾病。
影响因子：
12.7
作者：
Nelson PT;Smith CD;Abner EL;Wilfred BJ;Wang WX;Neltner JH;Baker M;Fardo DW;Kryscio RJ;Scheff SW;Jicha GA;Jellinger KA;Van Eldik LJ;Schmitt FA
通讯作者：
Schmitt FA