Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks.
Association of Maternal Age to Development and Progression of Retinopathy of Prematurity in Infants of Gestational Age under 33 Weeks.
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DOI：
10.1155/2014/187929
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发表时间：
2014
影响因子：
1.9
通讯作者：
Ozawa Y
中科院分区：
文献类型：
--
作者：
Uchida A;Miwa M;Shinoda H;Koto T;Nagai N;Mochimaru H;Tomita Y;Sasaki M;Ikeda K;Tsubota K;Ozawa Y
瞄准在胎龄（GA）小于33周的早产儿中，寻找早产儿视网膜病变（ROP）发展及其进展至需要激光治疗阶段风险的预测和指示性标志物。方法.我们回顾性分析了2005-2010年出生的197名早产儿的医疗记录，这些早产儿的GA < 33周，并在庆应义塾大学医院接受了眼部筛查。评估候选危险因素与ROP发生或进展之间的关联。结果在182名合格婴儿中（中位GA，29.1周;中位出生体重（BW），1028 g），84名（46%）发展为任何阶段的ROP，其中45名（25%）需要激光治疗。多元逐步回归分析表明，遗传算法（P = 0.002; 95%置信区间（CI），0.508-0.858），BW（P < 0.001; 95%CI，0.994-0.998），且母亲年龄较低（P = 0.032; 95%CI，0.819-0.991）是ROP发生和GA的危险因素（P < 0.001; 95% CI，0.387-0.609）和母亲年龄较低（P = 0.012; 95% CI，0.795-0.973）的妇女更适合激光治疗。当母亲年龄<33岁时，需要激光治疗的比值比为3.3。结论年轻母亲和低GA所生婴儿更容易发生ROP并进展。
Aim. To find predictive and indicative markers of risk for development of retinopathy of prematurity (ROP) and its progression to the stage requiring laser treatment, in premature infants whose gestational age (GA) was under 33 weeks. Methods. We retrospectively reviewed medical records of 197 premature infants born in 2005–2010 whose GA < 33 weeks and underwent eye screening at Keio University Hospital. The association between candidate risk factors and development or progression of ROP was assessed. Results. Among the 182 eligible infants (median GA, 29.1 weeks; median birth weight (BW), 1028 g), 84 (46%) developed any stage of ROP, of which 45 (25%) required laser treatment. Multivariate analysis using a stepwise method showed that GA (P = 0.002; 95% confidence interval (CI), 0.508–0.858), BW (P < 0.001; 95% CI, 0.994–0.998), and lower maternal age (P = 0.032; 95% CI, 0.819–0.991) were the risk factors for ROP development and GA (P < 0.001; 95% CI, 0.387–0.609) and lower maternal age (P = 0.012; 95% CI, 0.795–0.973) were for laser treatment. The odds ratio of requiring laser treatment was 3.3 when the maternal age was <33 years. Conclusion. ROP was more likely to be developed and progressed in infants born from younger mother and low GA.
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DOI：
10.1097/iae.0b013e3181ba246f
发表时间：
2010-02
期刊：
Retina (Philadelphia, Pa.)
影响因子：
--
作者：
Wu WC;Ong FS;Kuo JZ;Lai CC;Wang NC;Chen KJ;Hwang YS;Chen TL;Shih CP
通讯作者：
Shih CP
影响因子：
7.2
作者：
Jacobsson, B;Ladfors, L;Milsom, I
通讯作者：
Milsom, I
影响因子：
9.8
作者：
Chen, Jing;Smith, Lois E. H.
通讯作者：
Smith, Lois E. H.
DOI：
10.1016/s1084-2756(03)00119-2
发表时间：
2003-12-01
期刊：
Seminars in neonatology : SN
影响因子：
--
作者：
Smith, Lois E H
通讯作者：
Smith, Lois E H
影响因子：
5.4
作者：
Geronimus, AT
通讯作者：
Geronimus, AT