Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19.
Pathophysiology and Pathology of Acute Kidney Injury in Patients With COVID-19.
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DOI：
10.1053/j.ackd.2020.09.003
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发表时间：
2020-09
影响因子：
2.9
通讯作者：
Jhaveri KD
中科院分区：
文献类型：
--
作者：
Ng JH;Bijol V;Sparks MA;Sise ME;Izzedine H;Jhaveri KD
急性肾损伤（AKI）在2019冠状病毒病（COVID-19）住院患者中很常见，AKI的发生率为0.5%至80%。 AKI 发生的变异性归因于地理位置、种族/民族和疾病严重程度的差异。住院患者中的 AKI 与住院时间延长和院内死亡有关。即使 AKI 患者存活到出院，也有患慢性肾病或终末期肾病的风险。提高对 COVID-19 中 AKI 病理生理学的了解对于减轻和管理 AKI 以及提高在 COVID-19 期间发生 AKI 的患者的生存率至关重要。本文的目的是提供我们目前对 COVID-19 背景下 AKI 的病因学和病理生理学的了解。
Acute kidney injury (AKI) is common among hospitalized patients with Coronavirus Infectious Disease 2019 (COVID-19), with the occurrence of AKI ranging from 0.5% to 80%. The variability in the occurrence of AKI has been attributed to the difference in geographic locations, race/ethnicity, and severity of illness. AKI among hospitalized patients is associated with increased length of stay and in-hospital deaths. Even patients with AKI who survive to hospital discharge are at risk of developing chronic kidney disease or end-stage kidney disease. An improved knowledge of the pathophysiology of AKI in COVID-19 is crucial to mitigate and manage AKI and to improve the survival of patients who developed AKI during COVID-19. The goal of this article is to provide our current understanding of the etiology and the pathophysiology of AKI in the setting of COVID-19.
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