Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes.
Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes.
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DOI：
10.2337/dc09-1923
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发表时间：
2010-06
期刊：
影响因子：
16.2
通讯作者：
Utrecht Diabetic Encephalopathy Study Group
中科院分区：
文献类型：
--
作者：
de Bresser J;Tiehuis AM;van den Berg E;Reijmer YD;Jongen C;Kappelle LJ;Mali WP;Viergever MA;Biessels GJ;Utrecht Diabetic Encephalopathy Study Group
2型糖尿病与中度脑萎缩和较高的白色高信号（WMH）体积相关。这些脑成像异常如何随时间演变尚不清楚。本研究旨在量化2型糖尿病患者4年内的脑萎缩和WMH进展。共有55名2型糖尿病患者和28名年龄，性别和智商匹配的对照参与者进行了两次1.5T磁共振成像扫描，间隔4年。使用基于k-最近邻的概率分割进行全脑、外周脑脊液（CSF）、侧脑室和WMH的体积测量。所有体积均表示为颅内体积的百分比。进行线性回归分析，调整年龄和性别，以比较各组之间的脑容量，并确定2型糖尿病组内体积变化的决定因素。在基线时，2型糖尿病患者的总脑体积显著小于对照组，外周CSF体积显著大于对照组。在两组中，所有体积均随时间发生显著变化。2型糖尿病患者的侧脑室容积增加幅度大于对照组（4年内校正的组间差异平均值[95% CI]为0.11%[0.00 - 0.22]，P = 0.047）。与对照参与者相比，2型糖尿病患者侧脑室容积随时间的增加更大，表明2型糖尿病与多年来脑萎缩的缓慢增加有关。
Type 2 diabetes is associated with a moderate degree of cerebral atrophy and a higher white matter hyperintensity (WMH) volume. How these brain-imaging abnormalities evolve over time is unknown. The present study aims to quantify cerebral atrophy and WMH progression over 4 years in type 2 diabetes. A total of 55 patients with type 2 diabetes and 28 age-, sex-, and IQ-matched control participants had two 1.5T magnetic resonance imaging scans with a 4-year interval. Volumetric measurements of total brain, peripheral cerebrospinal fluid (CSF), lateral ventricles, and WMH were performed with k-nearest neighbor–based probabilistic segmentation. All volumes were expressed as percentage of intracranial volume. Linear regression analyses, adjusted for age and sex, were performed to compare brain volumes between the groups and to identify determinants of volumetric change within the type 2 diabetic group. At baseline, patients with type 2 diabetes had a significantly smaller total brain volume and larger peripheral CSF volume than control participants. In both groups, all volumes showed a significant change over time. Patients with type 2 diabetes had a greater increase in lateral ventricular volume than control participants (mean adjusted between-group difference in change over time [95% CI]: 0.11% in 4 years [0.00 to 0.22], P = 0.047). The greater increase in lateral ventricular volume over time in patients with type 2 diabetes compared with control participants shows that type 2 diabetes is associated with a slow increase of cerebral atrophy over the course of years.
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影响因子：
8.2
作者：
van den Berg, E.;Reijmer, Y. D.;de Bresser, J.;Kessels, R. P. C.;Kappelle, L. J.;Biessels, G. J.
通讯作者：
Biessels, G. J.
影响因子：
8.3
作者：
Tiehuis, Audrey M.;Van der Graaf, Yolanda;Mali, Willem P. T. M.
通讯作者：
Mali, Willem P. T. M.
影响因子：
8.2
作者：
Jongen, C.;van der Grond, J.;Kappelle, L. J.;Biessels, G. J.;Viergever, M. A.;Pluim, J. P. W.
通讯作者：
Pluim, J. P. W.
影响因子：
7.7
作者：
Manschot, SM;Brands, AMA;Biessels, GJ
通讯作者：
Biessels, GJ
影响因子：
5.7
作者：
Anbeek, P;Vincken, KL;van der Grond, J
通讯作者：
van der Grond, J