A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus.
A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus.
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DOI：
10.1007/s00125-009-1571-9
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发表时间：
2010-01
期刊：
影响因子：
8.2
通讯作者：
Biessels, G. J.
中科院分区：
文献类型：
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作者：
van den Berg, E.;Reijmer, Y. D.;de Bresser, J.;Kessels, R. P. C.;Kappelle, L. J.;Biessels, G. J.
2型糖尿病与认知功能的中度衰退有关，主要是在言语记忆、信息处理速度和执行功能方面。这种认知模式如何随着时间的推移而演变尚不确定。本研究旨在提供2型糖尿病患者认知功能减退随时间演变的详细信息。2002-2004年和2006-2008年，68名2型糖尿病患者和38名年龄、性别和估计智商相匹配的对照组进行了一项详细的神经心理学检查，包括涵盖5个认知领域的11项任务。记录血管和代谢决定因素。数据采用重复测量方差分析，包括组、时间和组×时间交互作用的主效应。在基线和4年随访检查中，与对照组相比，2型糖尿病患者的信息处理速度（z评分的平均差异[95% CI]-0.37 [-0.69，-0.05]）以及注意力和执行功能（-0.25 [-0.49，-0.01]）均出现中度下降。4年后，两组患者的抽象推理能力（-0.16 [-0.30，-0.02]）以及注意力和执行功能（-0.29 [-0.40，-0.17]）均有所下降，但与对照组相比，没有证据表明2型糖尿病患者的认知能力下降加快（均p > 0.05）。在患有2型糖尿病的非痴呆患者中，认知能力下降的程度是中等的，4年内的认知能力下降在很大程度上在正常衰老的范围内。显然，糖尿病相关的认知变化在很长一段时间内发展缓慢。
Type 2 diabetes mellitus is associated with moderate decrements in cognitive functioning, mainly in verbal memory, information-processing speed and executive functions. How this cognitive profile evolves over time is uncertain. The present study aims to provide detailed information on the evolution of cognitive decrements in type 2 diabetes over time. Sixty-eight patients with type 2 diabetes and 38 controls matched for age, sex and estimated IQ performed an elaborate neuropsychological examination in 2002–2004 and again in 2006–2008, including 11 tasks covering five cognitive domains. Vascular and metabolic determinants were recorded. Data were analysed with repeated measures analysis of variance, including main effects for group, time and the group × time interaction. Patients with type 2 diabetes showed moderate decrements in information-processing speed (mean difference in z scores [95% CI] −0.37 [−0.69, −0.05]) and attention and executive functions (−0.25 [−0.49, −0.01]) compared with controls at both the baseline and the 4 year follow-up examination. After 4 years both groups showed a decline in abstract reasoning (−0.16 [−0.30, −0.02]) and attention and executive functioning (−0.29 [−0.40, −0.17]), but there was no evidence for accelerated cognitive decline in the patients with type 2 diabetes as compared with controls (all p > 0.05). In non-demented patients with type 2 diabetes, cognitive decrements are moderate in size and cognitive decline over 4 years is largely within the range of what can be viewed in normal ageing. Apparently, diabetes-related cognitive changes develop slowly over a prolonged period of time.
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影响因子：
--
作者：
Kanaya, AM;Barrett-Connor, E;Yaffe, K
通讯作者：
Yaffe, K
影响因子：
8.2
作者：
Sandbaek, A.;Griffin, S. J.;Lauritzen, T.
通讯作者：
Lauritzen, T.
DOI：
10.1080/13803390802537636
发表时间：
2009-10
影响因子：
2.2
作者：
Fischer AL;de Frias CM;Yeung SE;Dixon RA
通讯作者：
Dixon RA
影响因子：
8.2
作者：
Manschot, S. M.;Biessels, G. J.;de Valk, H.;Algra, A.;Rutten, G. E. H. M.;van der Grond, J.;Kappelle, L. J.
通讯作者：
Kappelle, L. J.
影响因子：
9.9
作者：
Kumari, M;Marmot, M
通讯作者：
Marmot, M